methyl β-(trifluoroacetyl)vinyl sulfone | 329915-00-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: methyl β-(trifluoroacetyl)vinyl sulfone
• 英文别名: (E)-1,1,1-trifluoro-4-methylsulfonylbut-3-en-2-one
• CAS: 329915-00-6
• 化学式: C₅H₅F₃O₃S
• 分子量: 202.154
• InChiKey: VJLWGUJRQXTSLS-NSCUHMNNSA-N

物化性质

• 沸点：
  229.2±40.0 °C(Predicted)
• 密度：
  1.451±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  methyl β-(trifluoroacetyl)vinyl sulfone 在 水 作用下， 以 氘代乙腈 为溶剂， 生成
  参考文献：
  名称：

  摘要：

  Oxidation of beta-(trifluoroacetyl)vinyl sulfides afforded a series of the corresponding sulfones. The reactions of sulfones with various alkyl- and arylthiols were studied. These reactions provide the basis for a new procedure for the synthesis of beta-(trifluoroacetyl)vinyl sulfides.

  DOI：

  10.1023/a:1021620228529
• 作为产物：
  描述：

  1,1,1-trifluoro-4-(methylsulfonyl)but-3-ene-2,2-diol 在 氯化亚砜 作用下， 以 二氯甲烷 、 氘代乙腈 为溶剂， 反应 10.0h， 生成 methyl β-(trifluoroacetyl)vinyl sulfone
  参考文献：
  名称：

  摘要：

  Oxidation of beta-(trifluoroacetyl)vinyl sulfides afforded a series of the corresponding sulfones. The reactions of sulfones with various alkyl- and arylthiols were studied. These reactions provide the basis for a new procedure for the synthesis of beta-(trifluoroacetyl)vinyl sulfides.

  DOI：

  10.1023/a:1021620228529

文献信息

• Diels–Alder reactions of β-trifluoroacetylvinylsulfones
  作者：Arkady L Krasovsky、Valentine G Nenajdenko、Elizabeth S Balenkova

  DOI：10.1016/s0040-4020(00)00980-7

  日期：2001.1

  Diels–Alder reactions of β-trifluoroacetylvinylsulfones with 1,3-dienes in CH2Cl2 afforded corresponding mono- and polycycloadducts. A possibility of stereo- and regioselective cycloaddition was investigated. Elimination of sulfonyl group from cycloadducts leads to α,β-unsaturated trifluoromethylketones in good yields.

  β-三氟乙酰基乙烯基砜与1,3-二烯在CH 2 Cl 2中的Diels-Alder反应得到相应的单环和多环加合物。研究了立体和区域选择性环加成的可能性。从环加合物中消除磺酰基可产生高产率的α，β-不饱和三氟甲基酮。
• ——
  作者：A. L. Krasovsky、V. G. Nenajdenko、E. S. Balenkova

  DOI：10.1023/a:1015816217777

  日期：——

  The reactions of vinyl sulfides with p-sulfonylvinyl trifluoromethyl ketones afforded CF3-containing 3,4-dihydro-2H-pyrans. An attempt to synthesize 1,1,1-trifluoro-3-(methylthio)but-3-en-2-one resulted in its dimerization into a CF3-containing 3,4-dihydro-2H-pyran.
• ——
  作者：A. L. Krasovsky、V. G. Nenajdenko、E. S. Balenkova

  DOI：10.1023/a:1021620228529

  日期：——

  Oxidation of beta-(trifluoroacetyl)vinyl sulfides afforded a series of the corresponding sulfones. The reactions of sulfones with various alkyl- and arylthiols were studied. These reactions provide the basis for a new procedure for the synthesis of beta-(trifluoroacetyl)vinyl sulfides.