2,7-bis-(4-methyl-piperazin-1-yl)-3H-pyrimido[4,5-d]pyrimidin-4-one | 5726-71-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2,7-bis-(4-methyl-piperazin-1-yl)-3H-pyrimido[4,5-d]pyrimidin-4-one
• 英文别名: 2,7-Bis(4-methylpiperazin-1-yl)pyrimido[4,5-d]pyrimidin-4-ol；2,7-bis(4-methylpiperazin-1-yl)-6H-pyrimido[4,5-d]pyrimidin-5-one
• CAS: 5726-71-6
• 化学式: C₁₆H₂₄N₈O
• 分子量: 344.42
• InChiKey: OCAQSQAEMWOURW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  80.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• AMIDO-SUBSTITUTED AZOLE COMPOUNDS
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP3126337A2

  公开（公告）日：2017-02-08
• US9884063B2
  申请人：——

  公开号：US9884063B2

  公开（公告）日：2018-02-06
• [EN] AMIDO-SUBSTITUTED AZOLE COMPOUNDS<br/>[FR] COMPOSÉS AZOLE AMIDO-SUBSTITUÉS
  申请人：BAYER PHARMA AG

  公开号：WO2015150449A2

  公开（公告）日：2015-10-08

  The present invention relates to amido-substituted azole compounds of general formula (I), in which X1, X2, R1, R2, R4, R5, R7 and R8 are as defined in the claims which are inhibitors of TNKS1 and/or TNKS2, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.