6,8-bis(diethylamino)thieno(3,4-f)(1,2,3,4,5)pentathiepin

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 6,8-bis(diethylamino)thieno(3,4-f)(1,2,3,4,5)pentathiepin
• 英文别名: N6,N6,N8,N8-tetraethylthieno[3,4-f]pentathiepine-6,8-diamine；6-N,6-N,8-N,8-N-tetraethylthieno[3,4-f]pentathiepine-6,8-diamine
• 化学式: C₁₂H₂₀N₂S₆
• 分子量: 384.7
• InChiKey: USFSNINESMUBSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  161
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  6,8-bis(diethylamino)thieno(3,4-f)(1,2,3,4,5)pentathiepin 在 sodium cyanide 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以64%的产率得到N,N,N',N',N'',N'',N''',N'''-octaethylbisthieno[3,4-c:3’,4’-g][1,2,5,6]tetrathiocine-1,3,6,8-tetramine
  参考文献：
  名称：

  Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the feline immunodeficiency virus (FIV) as a model of HIV infection

  摘要：

  A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the feline immunodeficiency virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.12.047
• 作为产物：
  描述：

  三乙胺 在 三乙烯二胺 、 二氯化二硫 作用下， 以 氯仿 为溶剂， 反应 50.0h， 以30%的产率得到6,8-bis(diethylamino)thieno(3,4-f)(1,2,3,4,5)pentathiepin
  参考文献：
  名称：

  通过潜在的锌喷射机制研究五肽作为猫免疫缺陷病毒（FIV）抑制剂的功能，作为HIV感染的模型

  摘要：

  使用体外细胞培养方法，准备了一个小小的五肽衍生物衍生物文库，以评估其对抗猫免疫缺陷病毒（FIV）作为HIV模型的核衣壳蛋白功能的功效。这项研究导致了低毒性的纳摩尔活性化合物的开发。

  DOI：

  10.1002/cmdc.201800718

文献信息

• Synthesis and Identification of Pentathiepin-Based Inhibitors of Sporothrix brasiliensis
  作者：Christopher R. M. Asquith、Ana C. S. Machado、Luisa H. M. de Miranda、Lidia S. Konstantinova、Rodrigo Almeida-Paes、Oleg A. Rakitin、Sandro A. Pereira

  DOI：10.3390/antibiotics8040249

  日期：——

  Sporothrix brasiliensis is the causative agent of zoonotic sporotrichosis in Brazil and is currently referred to as the most virulent species among those of clinical importance within the genus. Sporotrichosis is an emergent disease that has come to the forefront over two decades with a recent hot spot of sporotrichosis infection emerging in the state of Rio de Janeiro. The source of these infections

  巴西Sporothrix brasiliensis是巴西人畜共患孢子菌病的病原体，目前被认为是该属中具有临床重要性的最强毒种。孢子丝虫病是一种新兴疾病，在过去的二十年中一直处于最前沿，最近在里约热内卢州出现了孢子丝虫病感染的热点地区。自1998年以来，仅在巴西里约热内卢就报告了4000多例此类感染的传染源。我们开发了一个稀有的pentathiepin环系统的重点文库，并确定了产生化合物21和22的有效替代模式。这些化合物比伊曲康唑更有效，伊曲康唑是目前治疗孢子体病的标准。
• Unprecedented Conversion of Triethylamine and Disulfur Dichloride into a Thienopentathiepin and a Heptathiocane
  作者：Lidia S. Konstantinova、Oleg A. Rakitin、Charles W. Rees、Ljudmila I. Souvorova、Denis G. Golovanov、Konstantin A. Lyssenko

  DOI：10.1021/ol034513x

  日期：2003.5.1

  [GRAPHIC]In a remarkable cascade reaction, triethylamine is converted into the thienopentathiepin 2a and the heptathlocane 3a by a preequilibrated solution of disulfur dichloride and DABCO in chloroform.
• Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection
  作者：Christopher R. M. Asquith、Tuomo Laitinen、Lidia S. Konstantinova、Graham Tizzard、Antti Poso、Oleg A. Rakitin、Regina Hofmann‐Lehmann、Stephen T. Hilton

  DOI：10.1002/cmdc.201800718

  日期：2019.2.19

  A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the feline immunodeficiency virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.

  使用体外细胞培养方法，准备了一个小小的五肽衍生物衍生物文库，以评估其对抗猫免疫缺陷病毒（FIV）作为HIV模型的核衣壳蛋白功能的功效。这项研究导致了低毒性的纳摩尔活性化合物的开发。
• Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the feline immunodeficiency virus (FIV) as a model of HIV infection
  作者：Christopher R.M. Asquith、Marina L. Meli、Lidia S. Konstantinova、Tuomo Laitinen、Antti Poso、Oleg A. Rakitin、Regina Hofmann-Lehmann、Karin Allenspach、Stephen T. Hilton

  DOI：10.1016/j.bmcl.2014.12.047

  日期：2015.3

  A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the feline immunodeficiency virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.