1-Isopropyl-4-(2-methoxy-phenyl)-piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-Isopropyl-4-(2-methoxy-phenyl)-piperazine
• 英文别名: 1-(2-Methoxyphenyl)-4-propan-2-ylpiperazine
• 化学式: C₁₄H₂₂N₂O
• 分子量: 234.341
• InChiKey: LUCSOMIVZJTSBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
  申请人：The Procter & Gamble Company

  公开号：US20040097560A1

  公开（公告）日：2004-05-20

  Compounds of Formula (I) 1 are effective in the treatment of a microbial infection.

  化合物式（I）1在治疗微生物感染方面具有良好的疗效。
• THIENOISOXAZOLYL-AND THIENYLPYRRAZOLYL PHENOXY SUBSTITUTED PROPYL DERIVATIVES USEFUL AS D4 ANTAGONISTS
  申请人：Fink M. David

  公开号：US20070004695A1

  公开（公告）日：2007-01-04

  The compounds are of the class thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives, useful as D 4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D 4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.

  这些化合物属于类别为噻唑异噁唑基和噻吩吡唑基苯氧基取代的丙基衍生物，可用作D4受体拮抗剂。这些化合物可用于治疗通过抑制D4受体介导的医疗状况。这些状况包括例如注意力缺陷多动障碍、强迫症、精神病、物质滥用、物质依赖、帕金森病、帕金森综合症、迟发性运动障碍、吉尔·德·拉·图雷特综合症、行为障碍和反抗行为障碍。发明的另一个方面是提供一种制药组合物、中间体和制备该类化合物的方法。
• N-BENZYL-4-METHYLENEAMINO-3-HYDROXY-2-PYRIDONES
  申请人：Warshakoon Namal Chithranga

  公开号：US20120115876A1

  公开（公告）日：2012-05-10

  Compounds of Formula (I) are effective in the treatment of a microbial infection.

  公式（I）的化合物对治疗微生物感染有效。
• Inhibitors of post-proline cleaving proteases
  申请人：Evans David M.

  公开号：US20080255126A1

  公开（公告）日：2008-10-16

  Novel compounds that are inhibitors of one or most post-proline cleaving proteases, e.g. dipeptidyl peptidase IV, according to general formula (1). R 1 is H or CN, X 1 is O, S, CH 2 , CHF, CF 2 , CH(CH 3 ), C(CH 3 ) 2 or CH(CN), and b is 1 or 2. G 1 is H or a group according to the formula —CH 2 —X 2 —(CH 2 ) a -G 3 and G 2 is H or a group according to the formula —CH 2 —(CH 2 9 a -G 3 , provided that one of G 1 and G 2 is H and the other is not H. X 2 is O, S, or CH 2 , and a is 0, 1 or 2, provided that when a is 1 then X 2 is CH 2 . G 3 is a group according to one of general formulae 2-4, where the variables have meaning given in the description. The compounds are useful in the treatment of i.a. type 2 diabetes and impaired glucose tolerance.
• INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20210299126A1

  公开（公告）日：2021-09-30

  The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.