Hepms

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Hepms
• 英文别名: [4-(2-hydroxyethyl)piperazin-4-ium-1-yl]methanesulfonate
• 化学式: C7H16N2O4S
• 分子量: 224.28
• InChiKey: FIBMVGIMBWAZQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  89.5
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Novel maxi-k channel blockers, methods of use and process for making the same
  申请人：Garcia L. Maria

  公开号：US20050239863A1

  公开（公告）日：2005-10-27

  This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions related to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of a mammalian species, particularly humans.

  本发明涉及在治疗青光眼和其他与患者眼内压力升高有关的疾病中使用强效钾通道阻滞剂或其制剂。本发明还涉及使用这些化合物为哺乳动物特别是人类的眼提供神经保护作用。
• Opthalmic compositions for treating ocular hypertension
  申请人：Chen Meng Hsin

  公开号：US20060148805A1

  公开（公告）日：2006-07-06

  This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

  本发明涉及在治疗青光眼和其他导致患者眼内压升高的情况中使用强效钾通道阻滞剂或其配方。本发明还涉及使用这些化合物为哺乳动物，特别是人类的眼提供神经保护效应。
• Ophthalmic compositions for treating ocular hypertension
  申请人：Boyd A. Edward

  公开号：US20060069256A1

  公开（公告）日：2006-03-30

  This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

  本发明涉及使用有效的钾离子通道阻滞剂或其制剂来治疗青光眼和其他导致患者眼内压升高的疾病。本发明还涉及使用这些化合物为哺乳动物（尤其是人类）的眼提供神经保护作用。
• Ophthalmic Compositions For Treating Ocular Hypertension
  申请人：Doherty B. James

  公开号：US20080032951A1

  公开（公告）日：2008-02-07

  This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

  本发明涉及公式（I）的有效钾通道阻滞剂化合物或其配方，用于治疗青光眼和其他导致患者眼内压升高的疾病。本发明还涉及使用这些化合物为哺乳动物眼部，特别是人类眼部提供神经保护作用。
• Ophthalmic Compositions for Treating Ocular Hypertension
  申请人：Gao Ying-Duo

  公开号：US20080097108A1

  公开（公告）日：2008-04-24

  This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

  本发明涉及公式（I）的有效钾通道阻滞剂化合物或其制剂，用于治疗青光眼和其他导致患者眼内压升高的疾病。本发明还涉及使用这些化合物为哺乳动物（尤其是人类）的眼提供神经保护作用。