4-Ethoxycarbonylpiperazine-1-carbodithioic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-Ethoxycarbonylpiperazine-1-carbodithioic acid
• 化学式: C₈H₁₄N₂O₂S₂
• 分子量: 234.3
• InChiKey: YUNAOGXAQZUUKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  65.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Piperazine mono(dithio)carbamate ester compounds and analogs thereof: preparation method and uses thereof
  申请人：Medinox, Inc.

  公开号：US20030149021A1

  公开（公告）日：2003-08-07

  In accordance with the present invention, there is provided a new class of compounds, i.e., mono(dithio)carbamate esters of piperazine and analogs thereof, with or without substituents. Also provided are methods for the preparation of invention compounds and the pharmaceutical use thereof in the treatment of a variety of pathological conditions, especially for the treatment of cancers. A lead compound has shown good anticancer activity with low toxicity.

  根据本发明，提供了一种新的化合物类，即吡哆醇及其类似物的单（二硫代）氨基甲酸酯，带或不带取代基。还提供了制备发明化合物的方法，以及在治疗各种病理状况，特别是治疗癌症方面的药物使用。一种主导化合物表现出良好的抗癌活性和低毒性。
• [EN] PIPERAZINE MONO(DITHIO)CARBAMATE ESTER COMPOUNDS AND ANALOGS THEREOF: PREPARATION METHOD AND USE THEREOF<br/>[FR] COMPOSES D'ESTER DE PIPERAZINE MONO(DITHIO)CARBAMATE ET LEURS ANALOGUES: PROCEDE DE PREPARATION ET UTILISATION
  申请人：PEKING UNIVERSITY SCHOOL OF PH

  公开号：WO2002096869A2

  公开（公告）日：2002-12-05

  In accordance with the present invention, there is provided a new class of compounds,i.e., mono(dithio)carbamate esters of piperazine and analogs thereof, with or without substituents. Also provided are methods for the preparation of invention compounds and the pharmaceutical use thereof in the treatment of a variety of pathological condition, especially for the treatment of cancers. A lead compound has shown good anticancer activity with low toxicity.