Ethyl 4-(4-amino-3,5-dichloro-6-pyrrolidin-1-ylpyridin-2-yl)piperazine-1-carboxylate | 676095-96-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Ethyl 4-(4-amino-3,5-dichloro-6-pyrrolidin-1-ylpyridin-2-yl)piperazine-1-carboxylate
• CAS: 676095-96-8
• 化学式: C₁₆H₂₃Cl₂N₅O₂
• 分子量: 388.297
• InChiKey: JBBLGEXTGNVRPN-UHFFFAOYSA-N

物化性质

• 沸点：
  608.5±55.0 °C(Predicted)
• 密度：
  1.382±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Ethyl 4-(4-amino-3,5-dichloro-6-pyrrolidin-1-ylpyridin-2-yl)piperazine-1-carboxylate 在 palladium on activated charcoal 甲酸铵 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 Ethyl 4-(4-amino-6-pyrrolidin-1-ylpyridin-2-yl)piperazine-1-carboxylate
  参考文献：
  名称：

  Parallel synthesis of 4-amino-2,6-dialkylamino-pyridines

  摘要：

  In this letter a fast and useful parallel synthesis approach to 4-amino-2,6-dialkylamino-pyridines is described starting from commercially available 2,6-difluoro-3,5-dichloro-pyridine. Both symmetrical and unsymmetrical derivatives have been synthesized respectively in two or three steps in good yields. The method described is mild, adaptable to combinatorial purposes and applicable to a variety of amines. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)02585-6
• 作为产物：
  描述：

  4-氨基-3,5-二氯-2,6-二氟吡啶 在 N,N-二异丙基乙胺 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 36.0h， 生成 Ethyl 4-(4-amino-3,5-dichloro-6-pyrrolidin-1-ylpyridin-2-yl)piperazine-1-carboxylate
  参考文献：
  名称：

  Parallel synthesis of 4-amino-2,6-dialkylamino-pyridines

  摘要：

  In this letter a fast and useful parallel synthesis approach to 4-amino-2,6-dialkylamino-pyridines is described starting from commercially available 2,6-difluoro-3,5-dichloro-pyridine. Both symmetrical and unsymmetrical derivatives have been synthesized respectively in two or three steps in good yields. The method described is mild, adaptable to combinatorial purposes and applicable to a variety of amines. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)02585-6

文献信息

• [EN] SUBSTITUTED PYRIDINE DERIVATIVES AS ANTITUMOR AGENT<br/>[FR] DERIVES DE PYRIDINE SUBSTITUES UTILISES COMME AGENT ANTITUMORAL
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2004024711A1

  公开（公告）日：2004-03-25

  The present invention relates to novel substituted pyridine derivatives active as Telomerase inhibitors, to the use of them as therapeutic agents, in particular as antitumoral agents, to a process for their preparation and to pharmaceutical compositions comprising them.

  本发明涉及一种新型取代吡啶衍生物，其作为端粒酶抑制剂具有活性，用作治疗剂，特别是抗肿瘤剂，以及一种制备它们的方法和包含它们的药物组合物。
• SUBSTITUTED PYRIDINE DERIVATIVES AS ANTITUMOR AGENT
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1546129A1

  公开（公告）日：2005-06-29
• Parallel synthesis of 4-amino-2,6-dialkylamino-pyridines
  作者：Maria Menichincheri、Domenico Fusar Bassini、Markus Gude、Mauro Angiolini

  DOI：10.1016/s0040-4039(02)02585-6

  日期：2003.1

  In this letter a fast and useful parallel synthesis approach to 4-amino-2,6-dialkylamino-pyridines is described starting from commercially available 2,6-difluoro-3,5-dichloro-pyridine. Both symmetrical and unsymmetrical derivatives have been synthesized respectively in two or three steps in good yields. The method described is mild, adaptable to combinatorial purposes and applicable to a variety of amines. (C) 2002 Elsevier Science Ltd. All rights reserved.