[(2R,3S,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: [(2R,3S,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate
• 化学式: C₁₀H₁₅N₅O₁₀P₂
• 分子量: 427.204
• InChiKey: XTWYTFMLZFPYCI-CPTYKQRNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  233
• 氢给体数：
  6
• 氢受体数：
  14

文献信息

• [EN] ADENOSINE THIOPHOSPHATE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS D'ADÉNOSINE THIOPHOSPHATE ET LEURS UTILISATIONS
  申请人：BAR-ILAN UNIV

  公开号：WO2016147185A1

  公开（公告）日：2016-09-22

  Novel adenosine 5'-thiophosphate derivatives, represented by Formulae (I) or (I*), and salts thereof, represented by Formulae (Ia) and (I*a), as defined in the specification, and uses thereof as antioxidants and/or P2Y1-R agonists, and/or in the treatment of medical conditions associated with oxidative stress and/or neurodegeneration, and in the treatment of Alzheimer's Disease in particular, are disclosed.