Adenosine-5'-monophosphate-propyl ester

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: Adenosine-5'-monophosphate-propyl ester
• 英文别名: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl propyl hydrogen phosphate
• 化学式: C₁₃H₂₀N₅O₇P
• 分子量: 389.3
• InChiKey: XAMXMSZRQHPMRX-QYVSTXNMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  175
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• [EN] ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME<br/>[FR] INHIBITEURS DE L'ACÉTYL-COA SYNTHÉTASE 2 (ACSS2) ET LEURS PROCÉDÉS D'UTILISATION
  申请人：THE WISTAR INST

  公开号：WO2020252407A1

  公开（公告）日：2020-12-17

  The present disclosure provides compounds that are ACSS2 inhibitors. In certain embodiments, the compounds of the disclosure are useful for treating and/or preventing certain types of cancer.

  本公开提供了一些ACSS2抑制剂化合物。在某些实施例中，本公开的化合物可用于治疗和/或预防某些类型的癌症。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• Sequestration of carbon dioxide with hydrogen to useful products
  申请人：UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

  公开号：US10227617B2

  公开（公告）日：2019-03-12

  Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.

  本文提供的基因工程微生物至少包括碳固定途径的一部分，在一个实施方案中，利用分子氢驱动二氧化碳固定。在一个实施方案中，经过改造的基因工程微生物可将乙酰 CoA、分子氢和二氧化碳转化为 3-羟基丙酸、4-羟基丁酸、乙酰 CoA 或它们的组合，其转化水平高于对照微生物。还可产生其他产物。本文还提供了将乙酰 CoA、分子氢和二氧化碳转化为 3-羟基丙酸酯、4-羟基丁酸酯、乙酰 CoA 或其组合的无细胞组合物。本文还提供了使用转基因微生物和无细胞组合物的方法。
• ADVANCED DRUG DEVELOPMENT AND MANUFACTURING
  申请人：Los Alamos National Security, LLC

  公开号：EP2084519A2

  公开（公告）日：2009-08-05
• X-RAY FLUORESCENCE ANALYSIS METHOD
  申请人：Los Alamos National Security, LLC

  公开号：EP2084519B1

  公开（公告）日：2012-08-01