(E)-N-t-butoxycarbonyl-6-aminohex-2-enyl methyl carbonate | 1008751-39-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: (E)-N-t-butoxycarbonyl-6-aminohex-2-enyl methyl carbonate
• 英文别名: methyl [(E)-6-[(2-methylpropan-2-yl)oxycarbonylamino]hex-2-enyl] carbonate
• CAS: 1008751-39-0
• 化学式: C₁₃H₂₃NO₅
• 分子量: 273.329
• InChiKey: RYUYPKNBVWRJMW-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  t-butyl 6-hydroxyhex-4-enylcarbamate 、 氯甲酸甲酯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 (Z)-N-t-butoxycarbonyl-6-aminohex-2-enyl methyl carbonate 、 (E)-N-t-butoxycarbonyl-6-aminohex-2-enyl methyl carbonate
  参考文献：
  名称：

  Polyfunctionalized Pyrrolidines by Ugi Multicomponent Reaction Followed by Palladium-Mediated S_N2‘ Cyclizations

  摘要：

  [GRAPHICS]A 4-component Ugi reaction with a suitable isocyanide, followed by a novel secondary transformation involving a Pd(II)-mediated (R-5 = H) or a Pd(0)-mediated (RI = CO2Me) S(N)2' cyclization to give highly functionalized N-acyl-2-vinylpyrrolidines, is reported. The overall yields are usually good and in most cases the Pd(0)-catalyzed reaction gave the final product in almost quantitative yield.

  DOI：

  10.1021/jo702087x

文献信息

• Polyfunctionalized Pyrrolidines by Ugi Multicomponent Reaction Followed by Palladium-Mediated S_N2‘ Cyclizations
  作者：Luca Banfi、Andrea Basso、Valentina Cerulli、Giuseppe Guanti、Renata Riva

  DOI：10.1021/jo702087x

  日期：2008.2.1

  [GRAPHICS]A 4-component Ugi reaction with a suitable isocyanide, followed by a novel secondary transformation involving a Pd(II)-mediated (R-5 = H) or a Pd(0)-mediated (RI = CO2Me) S(N)2' cyclization to give highly functionalized N-acyl-2-vinylpyrrolidines, is reported. The overall yields are usually good and in most cases the Pd(0)-catalyzed reaction gave the final product in almost quantitative yield.