2,4-difluoro-5-[4-(2-hydroxyethyl)piperazin-1-yl]-N-(1H-indazol-6-yl)benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2,4-difluoro-5-[4-(2-hydroxyethyl)piperazin-1-yl]-N-(1H-indazol-6-yl)benzamide
• 化学式: C₂₀H₂₁F₂N₅O₂
• 分子量: 401.4
• InChiKey: LUMLAJAVOADZJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  84.5
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] NOVEL 2,4-DIFLUOROBENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS<br/>[FR] NOUVEAUX DERIVES DE 2,4-DIFLUOROBENZAMIDE UTILISES COMME AGENTS ANTIVIRAUX
  申请人：DONG HWA PHARM IND CO LTD

  公开号：WO2003002518A1

  公开（公告）日：2003-01-09

  2,4-difluorobenzamide derivatives and their pharmaceutically acceptable salts, represented by following formula (1), are described in which the derivatives have excellent inhibitory effects on proliferation of hepatitis B virus (HBV) and hepatitis C virus (HCV) so that they can be easily used as an effective ingredient against viruses. In addition, the process for preparing the derivatives is also described.