[5-(4-Fluoro-benzyloxy)-3-hydroxy-benzofuran-2-yl]-2-oxo-acetic acid methyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: [5-(4-Fluoro-benzyloxy)-3-hydroxy-benzofuran-2-yl]-2-oxo-acetic acid methyl ester
• 英文别名: Methyl 2-[5-[(4-fluorophenyl)methoxy]-3-hydroxy-benzofuran-2-yl]-2-oxo-acetate；methyl 2-[5-[(4-fluorophenyl)methoxy]-3-hydroxy-1-benzofuran-2-yl]-2-oxoacetate
• 化学式: C₁₈H₁₃FO₆
• 分子量: 344.296
• InChiKey: SZTWIJTUNNBNHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  86
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Inhibitor for enzyme having two divalent metal ions as active centers
  申请人：——

  公开号：US20040039060A1

  公开（公告）日：2004-02-26

  A pharmaceutical composition for use as an inhibitor of an enzyme having two divalent metal ions as an active center was found. It is possible to inhibit the activity of an enzyme by a compound capable of chelating both of the two divalent metal ions.

  发现了一种用作酶抑制剂的药物组合物，该酶具有两个二价金属离子作为活性中心。能够通过一种化合物来螯合这两个二价金属离子，从而抑制酶活性。
• Inhibitor for enzyme having two divalent metal ions as active center
  申请人：Kiyama Ryuichi

  公开号：US20100068695A1

  公开（公告）日：2010-03-18

  A pharmaceutical composition for use as an inhibitor of an enzyme having two divalent metal ions as an active center was found. It is possible to inhibit the activity of an enzyme by a compound capable of chelating both of the two divalent metal ions.

  发现了一种用作酶抑制剂的药物组合物，该酶具有两个二价金属离子作为活性中心。通过化合物能够螯合这两个二价金属离子中的任意一个或两个，从而抑制酶的活性。
• INHIBITOR FOR ENZYME HAVING TWO DIVALENT METAL IONS AS ACTIVE CENTERS
  申请人：SHIONOGI & CO., LTD.

  公开号：EP1297834A1

  公开（公告）日：2003-04-02

  A pharmaceutical composition for use as an inhibitor of an enzyme having two divalent metal ions as an active center was found. It is possible to inhibit the activity of an enzyme by a compound capable of chelating both of the two divalent metal ions.

  发现了一种用作具有两个二价金属离子作为活性中心的酶的抑制剂的药物组合物。 能够螯合两种二价金属离子的化合物可以抑制酶的活性。