1-[(3-chlorophenyl)methyl]-9-nitro-3,4-dihydro-2H-benzothiopheno[3,2-e][1,4]diazepin-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻烯杂卓类
• 英文名称: 1-[(3-chlorophenyl)methyl]-9-nitro-3,4-dihydro-2H-benzothiopheno[3,2-e][1,4]diazepin-5-one
• 英文别名: 1-[(3-chlorophenyl)methyl]-9-nitro-3,4-dihydro-2H-[1]benzothiolo[3,2-e][1,4]diazepin-5-one
• 化学式: C18H14ClN3O3S
• 分子量: 387.8
• InChiKey: FHLQYEXSKHKXMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PYRROLIDINE DERIVATIVES HAVING PHOSPHOLIPASE A2 INHIBITORY ACTIVITY
  申请人：SHIONOGI & CO., LTD.

  公开号：EP0976748A1

  公开（公告）日：2000-02-02

  A compound represented by the formula (I): wherein, for example, R1 is optionally substituted aralkyl, Z is nitrogen atom which optionally substituted with alkyl, X1 is -CH2NHCO-, X2 is phenylene, X3 is a bond, Y2 is optionally substituted aryl, B is oxygen atom, its pharmaceutically acceptable salt, or hydrate thereof and a pharmaceutical composition which contains them as an active ingredient.

  由式(I)代表的化合物： 其中，例如，R1 是任选取代的芳烷基，Z 是任选被烷基取代的氮原子，X1 是-CH2NHCO-，X2 是亚苯基，X3 是键，Y2 是任选取代的芳基，B 是氧原子、其药学上可接受的盐或水合物，以及含有它们作为活性成分的药物组合物。
• PREVENTIVES OR REMEDIES FOR ARRHYTHMIA
  申请人：SHIONOGI & CO., LTD.

  公开号：EP1240906A1

  公开（公告）日：2002-09-18

  A composition for treating or preventing arrhythmia containing as an active ingredient a cPLA2 inhibitor, for example a compound represented by formula (I): wherein R1 is optionally substituted aralkyl or the like; Z is -S- or the like; X1 is -(CH2)s-N(R18)-CO- (wherein R18 is hydrogen atom or the like, s is an integer of 0 to 3) or the like; X2 is optionally substituted arylene or the like; X3 is a bond or the like; A, B, and E are each independently oxygen atom or sulfur atom; D is hydrogen atom or the like; Y1 is -(CH2)mCO- (m is an integer of 0 to 3) or the like; Y2 is optionally substituted aryl or the like.

  一种治疗或预防心律失常的组合物，其活性成分含有 cPLA2 抑制剂，例如由式 (I) 代表的化合物： 其中 R1 是任选取代的芳烷基或类似物； Z 是-S-或类似物； X1 是-(CH2)s-N(R18)-CO-（其中 R18 是氢原子或类似物，s 是 0 至 3 的整数）或类似物； X2 是任选取代的芳烯或类似物；X3是键或类似物；A、B和E各自独立地是氧原子或硫原子；D是氢原子或类似物；Y1是-(CH2)mCO- (m是0至3的整数)或类似物；Y2是任选取代的芳基或类似物。
• Diazepinones as antiviral agents
  申请人：——

  公开号：US20040116410A1

  公开（公告）日：2004-06-17

  The invention is novel compounds of formula (I) which exhibit an improved therapeutic index and improved metabolic stability which are useful in the treatment and/or prevention of herpes viral infections. Novel intermediates useful in the synthesis of the final compounds are also part of the invention.
• US6147100A
  申请人：——

  公开号：US6147100A

  公开（公告）日：2000-11-14
• US6924301B1
  申请人：——

  公开号：US6924301B1

  公开（公告）日：2005-08-02