6-ethyl-5-(4-phenylpiperazin-1-yl)pyrimidine-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-ethyl-5-(4-phenylpiperazin-1-yl)pyrimidine-2,4-diamine
• 英文别名: 6-Ethyl-5-[4-phenyl-1-piperazinyl]-2,4-pyrimidinediamine
• 化学式: C₁₆H₂₂N₆
• 分子量: 298.391
• InChiKey: LFPYDHLDVYWBQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  84.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] DHFR INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO<br/>[FR] INHIBITEURS DE DHFR, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
  申请人：VYERA PHARMACEUTICALS LLC

  公开号：WO2019032458A1

  公开（公告）日：2019-02-14

  The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using novel inhibitors of the invention.

  该发明涉及二氢叶酸还原酶抑制剂及其药物制剂。该发明还涉及使用该发明的新型抑制剂治疗寄生虫感染的方法，如弓形虫、克鲁兹氏锥虫、疟原虫、布鲁氏锥虫或印度利马锥虫感染。
• Compositions and methods for treating infections
  申请人：Vyera Pharmaceuticals, LLC

  公开号：US10774073B2

  公开（公告）日：2020-09-15

  The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.

  本发明涉及二氢叶酸还原酶抑制剂及其药物制剂。本发明还涉及使用本发明的新型抑制剂治疗寄生虫感染的方法，如淋病双球菌、克鲁兹双球菌、恶性疟原虫、布鲁西双球菌或大肠杆菌感染。
• COMPOSITIONS AND METHODS FOR TREATING INFECTIONS
  申请人：THOMAS Stephen

  公开号：US20190077794A1

  公开（公告）日：2019-03-14

  The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei , or L. major infections, using the novel inhibitors of the invention.
• DHFR INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO
  申请人：Vyera Pharmaceuticais LLC

  公开号：US20200270233A1

  公开（公告）日：2020-08-27

  The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T gondii, T. cruzi, P. falciparum, T. brucei , or L. major infections, using the novel inhibitors of the invention.