(2-nitro-5-piperazin-1-yl-phenyl)-(2-phenoxy-ethyl)-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (2-nitro-5-piperazin-1-yl-phenyl)-(2-phenoxy-ethyl)-amine
• 英文别名: Benzenamine, 2-nitro-N-(2-phenoxyethyl)-5-(1-piperazinyl)-；2-nitro-N-(2-phenoxyethyl)-5-piperazin-1-ylaniline
• 化学式: C₁₈H₂₂N₄O₃
• 分子量: 342.398
• InChiKey: CMOZNIKQPGDONT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  82.4
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Nitro-substituted phenyl-piperazine compounds, their preparation and use in medicaments
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1676842A1

  公开（公告）日：2006-07-05

  The present invention relates to nitro-substituted phenyl-piperazine compounds of general formula I, a process for their preparation, medicaments comprising said nitro-substituted phenyl-piperazine compounds as well as the use of said nitre-substituted phenyl-piperazine compounds for the preparation of medicaments, which are particularly suitable for the prophylaxis and/or treatment of disorders or diseases that are at least partially mediated via 5-HT6 receptors.

  本发明涉及一般式I的硝基取代苯基哌嗪化合物，其制备方法，包含所述硝基取代苯基哌嗪化合物的药物，以及利用所述硝基取代苯基哌嗪化合物制备药物，该药物特别适用于预防和/或治疗至少部分通过5-HT6受体介导的疾病或疾病。
• TETRAHYDROINDOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS
  申请人：Page Patrick

  公开号：US20100120749A1

  公开（公告）日：2010-05-13

  The present invention is related to tetrahydroindole derivatives of Formula (I), pharmaceutical composition thereof, methods of preparation thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及式（I）的四氢吲哚衍生物，其药物组成物，其制备方法以及它们用于治疗和/或预防与尼克酰胺腺嘌呤二核苷酸磷酸酰化酶（NADPH氧化酶）相关的疾病或症状的用途。
• Combination of a NMDA-receptor ligand and a compound with 5-HT6 receptor affinity
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1902733A1

  公开（公告）日：2008-03-26

  The present invention relates to an active substance combination comprising at least one compound with 5-HT6 receptor affinity, and at least NMDA-receptor ligand, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.

  本发明涉及一种由至少一种具有 5-HT6 受体亲和力的化合物和至少一种 NMDA 受体配体组成的活性物质组合、一种包含所述活性物质组合的药物，以及使用所述活性物质组合制造药物。
• Tetrahydroindole derivatives as NADPH Oxidase inhibitors
  申请人：GenKyo Tex

  公开号：EP2000176A1

  公开（公告）日：2008-12-10

  The present invention is related to tetrahydroindole derivatives of Formula (I), pharmaceutical composition thereof, methods of preparation thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adcninc dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及式（I）的四氢吲哚衍生物、其药物组合物、其制备方法及其用于治疗和/或预防与烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NADPH 氧化酶）有关的疾病或病症。
• NITRO-SUBSTITUTED PHENYL-PIPERAZINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1851210B1

  公开（公告）日：2011-10-19