N-{4-[4-(2-Methyl-quinolin-4-yl)-piperazine-1-sulfonyl]-phenyl}-acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-{4-[4-(2-Methyl-quinolin-4-yl)-piperazine-1-sulfonyl]-phenyl}-acetamide
• 英文别名: N-[4-[4-(2-methylquinolin-4-yl)piperazin-1-yl]sulfonylphenyl]acetamide
• 化学式: C₂₂H₂₄N₄O₃S
• 分子量: 424.5
• InChiKey: UCDZGGRIXDWJHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  91
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• COMPOSITION COMPRISING CYP4A-INHIBITING COMPOUND AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING METABOLIC DISEASES
  申请人：Korea Basic Science Institute

  公开号：EP3900725A1

  公开（公告）日：2021-10-27

  The present invention relates to a composition comprising a CYP4A-inhibiting compound as an active ingredient for preventing or treating metabolic diseases, more specifically to a composition comprising the compound expressed by chemical formula 1 of the present invention or pharmaceutically acceptable salt thereof as an active ingredient for preventing, ameliorating or treating metabolic diseases.

  本发明涉及一种包含 CYP4A 抑制化合物的组合物，作为预防或治疗代谢性疾病的活性成分，更具体地说，涉及一种包含本发明化学式 1 所表示的化合物或其药学上可接受的盐的组合物，作为预防、改善或治疗代谢性疾病的活性成分。
• [EN] COMPOSITION COMPRISING CYP4A-INHIBITING COMPOUND AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING METABOLIC DISEASES<br/>[FR] COMPOSITION COMPRENANT UN COMPOSÉ INHIBANT LE CYP4A UTILISÉ COMME PRINCIPE ACTIF POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES MÉTABOLIQUES<br/>[KO] CYP4A 저해 화합물을 유효성분으로 포함하는 대사질환의 예방 또는 치료용 조성물
  申请人：KOREA BASIC SCIENCE INST

  公开号：WO2020130696A1

  公开（公告）日：2020-06-25

  본 발명은 CYP4A 저해 화합물을 유효성분으로 포함하는 대사질환의 예방 또는 치료용 조성물에 관한 것으로, 보다 상세하게는 본 발명에서 제공하는 화학식 1의 화합물 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 대사질환의 예방, 개선, 치료용 조성물에 관한 것이다.