ethyl 6-(2-thienyl)imidazo[2,1-b]thiazole-3-carboxylate | 943986-27-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并噻唑类
• 英文名称: ethyl 6-(2-thienyl)imidazo[2,1-b]thiazole-3-carboxylate
• 英文别名: Ethyl 6-thiophen-2-ylimidazo[2,1-b][1,3]thiazole-3-carboxylate；ethyl 6-thiophen-2-ylimidazo[2,1-b][1,3]thiazole-3-carboxylate
• CAS: 943986-27-4
• 化学式: C₁₂H₁₀N₂O₂S₂
• 分子量: 278.356
• InChiKey: RWKRUPPTOROVES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  100
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 6-(2-thienyl)imidazo[2,1-b]thiazole-3-carboxylate 在 溶剂黄146 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 0.5h， 以50%的产率得到ethyl 5-nitroso-6-(2-thienyl)imidazo[2,1-b]thiazole-3-carboxylate
  参考文献：
  名称：

  Synthesis of Ethyl 8‐Aryl‐8‐hydroxy‐3‐oxo‐8H[1,2,4]oxadiazolo‐[3,4‐c][1,4]thiazine‐5‐carboxylates by Ring‐Expansion Rearrangement

  摘要：

  The title compounds were prepared by the ring-ring interconversion of ethyl 5-nitroso-6-arylimidazo[2,1-b] thiazole-3-carboxylates with hydrochloric acid. The effect of electron-withdrawing substituent in the thiazole ring on the general applicability of the ring-ring interconversion has been also evaluated.

  DOI：

  10.1080/00397910701265945
• 作为产物：
  描述：

  2-溴-1-(2-THIENYL)-1-ETHANONE 、 2-氨基噻唑-4-甲酸乙酯 以 乙醇 为溶剂， 反应 14.0h， 以60%的产率得到ethyl 6-(2-thienyl)imidazo[2,1-b]thiazole-3-carboxylate
  参考文献：
  名称：

  Synthesis of Ethyl 8‐Aryl‐8‐hydroxy‐3‐oxo‐8H[1,2,4]oxadiazolo‐[3,4‐c][1,4]thiazine‐5‐carboxylates by Ring‐Expansion Rearrangement

  摘要：

  The title compounds were prepared by the ring-ring interconversion of ethyl 5-nitroso-6-arylimidazo[2,1-b] thiazole-3-carboxylates with hydrochloric acid. The effect of electron-withdrawing substituent in the thiazole ring on the general applicability of the ring-ring interconversion has been also evaluated.

  DOI：

  10.1080/00397910701265945

文献信息

• Synthesis of Ethyl 8‐Aryl‐8‐hydroxy‐3‐oxo‐8<i>H</i>[1,2,4]oxadiazolo‐[3,4‐<i>c</i>][1,4]thiazine‐5‐carboxylates by Ring‐Expansion Rearrangement
  作者：Rajesh Koti、Vinayak Hegde、Gundurao Kolavi,、Imtiyaz Ahmed Khazi

  DOI：10.1080/00397910701265945

  日期：2007.5.1

  The title compounds were prepared by the ring-ring interconversion of ethyl 5-nitroso-6-arylimidazo[2,1-b] thiazole-3-carboxylates with hydrochloric acid. The effect of electron-withdrawing substituent in the thiazole ring on the general applicability of the ring-ring interconversion has been also evaluated.