N-(m-Tolyloxyacetyl)-piperidin | 2021-02-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(m-Tolyloxyacetyl)-piperidin
• 英文别名: 1-m-tolyloxyacetyl-piperidine；2-(3-Methylphenoxy)-1-piperidin-1-ylethanone
• CAS: 2021-02-5
• 化学式: C₁₄H₁₉NO₂
• mdl: MFCD01009035
• 分子量: 233.31
• InChiKey: LBSRICZHWRGMSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(m-Tolyloxyacetyl)-piperidin 在 2-氟吡啶 、 三氟甲磺酸酐 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成 1-(6-methyl-1-benzofuran-3-yl)piperidine
  参考文献：
  名称：

  Mild and Efficient Tf2O-Mediated Synthesis of 3-Amino-1-benzofurans

  摘要：

  A mild and efficient procedure has been developed for the synthesis of 3-amino-1-benzofurans by intramolecular cyclization of the corresponding N,N-disubstituted phenoxyacetamides under the action of trifluoromethanesulfonic anhydride in the presence of 2-fluoropyridine in methylene chloride at room temperature. The proposed novel and efficient protocol has been successfully utilized to obtain a wide series of 3-amino-1-benzofurans with various substituents in the benzene ring and amino group.

  DOI：

  10.1134/s1070428019090173

文献信息

• Mild and Efficient Tf2O-Mediated Synthesis of 3-Amino-1-benzofurans
  作者：P. Anil、A. Chatterjee、S. Vijaya Laxmi

  DOI：10.1134/s1070428019090173

  日期：2019.9

  A mild and efficient procedure has been developed for the synthesis of 3-amino-1-benzofurans by intramolecular cyclization of the corresponding N,N-disubstituted phenoxyacetamides under the action of trifluoromethanesulfonic anhydride in the presence of 2-fluoropyridine in methylene chloride at room temperature. The proposed novel and efficient protocol has been successfully utilized to obtain a wide series of 3-amino-1-benzofurans with various substituents in the benzene ring and amino group.