1-(5-Chloro-2-methylphenyl)-4-thiophen-2-ylsulfonylpiperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(5-Chloro-2-methylphenyl)-4-thiophen-2-ylsulfonylpiperazine
• 化学式: C₁₅H₁₇ClN₂O₂S₂
• 分子量: 356.9
• InChiKey: KARJUULPUPUHPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  77.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA<br/>[FR] INHIBITEURS DU CANAL ANIONIQUE DE SURFACE DE PLASMODIUM POUR LE TRAITEMENT OU LA PRÉVENTION DE LA MALARIA
  申请人：US HEALTH

  公开号：WO2012142125A2

  公开（公告）日：2012-10-18

  The invention provides methods of treating or preventing malaria comprising administering to an animal an effective amount of acompound of formula (I): Q-Y-R1-R2 (I), wherein Q, Y, R1, and R2 are as described herein. Methods of inhibiting a plasmodial surface anion channel of a parasite in an animal are also provided. The invention also provides pharmaceutical compositions comprising a compound represented by formula (I) in combination with any one or more compounds represented by formulas II, V, and VI. Use of the pharmaceutical compositions for treating or preventing malaria or for inhibiting a plasmodial surface anion channel in animals including humans are also provided. Also provided by the invention are clag3 amino acid sequences and related nucleic acids, vectors, host cells, populations of cells, antibodies, and pharmaceutical compositions.