5-Chloro-7-[(4-pyridin-2-ylpiperazin-1-ium-1-yl)methyl]quinolin-8-olate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-Chloro-7-[(4-pyridin-2-ylpiperazin-1-ium-1-yl)methyl]quinolin-8-olate
• 化学式: C19H19ClN4O
• 分子量: 354.8
• InChiKey: OPEJNANYABTIGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  52.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Dopamine D2 receptor ligands
  申请人：The Broad Institute, Inc.

  公开号：US10633336B2

  公开（公告）日：2020-04-28

  The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity. The present invention relates to novel compounds that modulate dopamine D2 receptors. In particular, compounds of the present invention show functional selectivity at the dopamine D2 receptors and exhibit selectivity downstream of the D2 receptors, on the 0-arrestin pathway and/or on the cAMP pathway.

  本发明涉及新型多巴胺D2受体配体。本发明进一步涉及具有功能偏倚的多巴胺 D2 受体配体，以及使用这些化合物治疗或预防与多巴胺能活性失调相关的中枢神经系统和全身性疾病。本发明涉及调节多巴胺 D2 受体的新型化合物。特别是，本发明的化合物在多巴胺 D2 受体上表现出功能选择性，并在 D2 受体下游、0-arrestin 通路和/或 cAMP 通路上表现出选择性。
• DOPAMINE D2 RECEPTOR LIGANDS
  申请人：The Broad Institute, Inc.

  公开号：EP3233799B1

  公开（公告）日：2021-05-19
• METHOD AND MEANS FOR PREVENTING AND INHIBITING TYPE III SECRETION IN INFECTIONS CAUSED BY GRAM-NEGATIVE BACTERIA
  申请人：Elofsson Mikael

  公开号：US20100099674A1

  公开（公告）日：2010-04-22

  A means for decreasing bacterial virulence in a mammal including man or in a plant by inhibition of the Type III secretion system at concentrations that do not prevent or substantially reduce bacterial growth comprises an N-substituted 7-quinolylmethyl amine, in particular one that is further substituted in 5- and 8-position on the quinoline ring. A corresponding therapeutic method and a pharmaceutical composition are also disclosed.
• [EN] METHOD AND MEANS FOR PREVENTING AND INHIBITING TYPE III SECRETION IN INFECTIONS CAUSED BY GRAM-NEGATIVE BACTERIA<br/>[FR] PROCÉDÉ ET MOYENS POUR PRÉVENIR ET INHIBER UNE SÉCRÉTION DE TYPE III DANS DES INFECTIONS PROVOQUÉES PAR UNE BACTÉRIE À GRAM-NÉGATIF
  申请人：INNATE PHARMACEUTICALS AB

  公开号：WO2008115118A1

  公开（公告）日：2008-09-25

  [EN] A means for decreasing bacterial virulence in a mammal including man or in a plant by inhibition of the Type III secretion system at concentrations that do not prevent or substantially reduce bacterial growth comprises an N-substituted 7-quinolylmethyl amine, in particular one that is further substituted in 5- and 8-position on the quinoline ring. A corresponding therapeutic method and a pharmaceutical composition are also disclosed.
  [FR] L'invention concerne des moyens pour diminuer la virulence bactérienne ou dans un végétal ou chez un mammifère, dont l'homme, par inhibition du système de sécrétion de type III à des concentrations qui n'empêchent pas ou ne réduisent sensiblement pas la croissance bactérienne et qui incluent une 7-quinolylméthylamine N-substituée, en particulier une 7-quinolylméthylamine N-substituée qui est substituée à nouveau en position 5 et en position 8 sur le cycle de quinoline. Un procédé thérapeutique correspondant et une composition pharmaceutique sont également décrits.