肥酸4-[(4-氨基环己基)甲基]环己烷-1-胺吖庚环-2-酮己烷-1,6-二胺 | 769944-51-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 肥酸4-[(4-氨基环己基)甲基]环己烷-1-胺吖庚环-2-酮己烷-1,6-二胺
• 中文别名: 2-(4-氯苯基)哌嗪；R-2-(4-氯苯基)哌嗪
• 英文名称: (R)-2-(4-chlorophenyl)piperazine
• 英文别名: (R)-2-(4-chlorophenyl)hexahydropyrazine；(2R)-2-(4-chlorophenyl)piperazine
• CAS: 769944-51-6
• 化学式: C₁₀H₁₃ClN₂
• 分子量: 196.68
• InChiKey: OTOVNNDSINVUBR-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933599090

反应信息

• 作为产物：
  描述：

  (R)-2-(4-chlorophenyl)-1,4-di(2-propenyl)hexahydropyrazine dihydrochloride 在 ruthenium trichloride sodium hydroxide 作用下， 以 水 、 甲苯 为溶剂， 反应 68.0h， 生成 肥酸4-[(4-氨基环己基)甲基]环己烷-1-胺吖庚环-2-酮己烷-1,6-二胺
  参考文献：
  名称：

  EP2119709

  摘要：

  公开号：

文献信息

• [EN] 2, 3, 6-TRISUBSTITUTED-4-PYRIMIDONE DERIVATIVES<br/>[FR] DERIVES DE 2,3,6-TRISUBSTITUE 4-PYRIMIDONE
  申请人：MITSUBISHI PHARMA CORP

  公开号：WO2004085408A1

  公开（公告）日：2004-10-07

  A pyrimidone derivative having tau protein kinase 1 inhibitory activity which is represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof; useful for prventive and/or therapeutic treatment of diseass such as neurodegenerative diseases (e.g. Alzheimer disease); wherein Q represents CH or nitrogen atom; R represents a C1-C12 alkyl group; the ring of Formula (I): represents piperazine ring or piperidine ring; each X independently represents a C1-C8 alkyl group, an optionally partially hydrogenated C6-C10 aryl ring, an indan ring or the like; m represents an integer of 1 to 3; each Y independently represents a halogen atom, a hydroxy group, a cyano group, a C1-C6 alkyl group or the like; n represents an integer of 0 to 8; when X and Y or two Y groups are attached on the same carbon atom, they may combine to each other to form a C2-C6 alkylene group.

  一种具有tau蛋白激酶1抑制活性的嘧啶酮衍生物，其由化学式（I）或其盐、溶剂合物或水合物表示；用于预防和/或治疗神经退行性疾病（例如阿尔茨海默病）；其中Q代表CH或氮原子；R代表C1-C12烷基基团；化学式（I）的环：代表哌嗪环或哌啶环；每个X独立地代表C1-C8烷基基团、可选择性部分氢化的C6-C10芳环、茚环或类似物；m代表1到3的整数；每个Y独立地代表卤素原子、羟基、氰基、C1-C6烷基基团或类似物；n代表0到8的整数；当X和Y或两个Y基团连接在同一碳原子上时，它们可以结合形成C2-C6烷基基团。
• 2,3,6-Trisubstituted-4-pyrimidone derivatives
  申请人：Watanabe Kazutoshi

  公开号：US20060252768A1

  公开（公告）日：2006-11-09

  A pyrimidone derivative having tau protein kinase 1 inhibitory activity which is represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof; useful for prventive and/or therapeutic treatment of diseass such as neurodegenerative diseases (e.g. Alzheimer disease); wherein Q represents CH or nitrogen atom; R represents a C 1 -C 12 alkyl group; the ring of Formula (I): represents piperazine ring or piperidine ring; each X independently represents a C 1 -C 8 alkyl group, an optionally partially hydrogenated C 6 -C 10 aryl ring, an indan ring or the like; m represents an integer of 1 to 3; each independently represents a halogen atom, a hydroxy group, a cyano group, a C 1 -C 6 alkyl group or the like; n represents an integer of 0 to 8; when X and Y or two Y groups are attached on the same carbon atom, they may combine to each other to form a C 2 -C 6 alkylene group.

  具有tau蛋白激酶1抑制活性的嘧啶酮衍生物，其由式（I）或其盐、溶剂化物或水合物表示; 用于预防和/或治疗神经退行性疾病（例如阿尔茨海默病）等疾病; 其中Q表示CH或氮原子; R表示C1-C12烷基; 公式（I）的环表示哌嗪环或哌啶环; 每个X独立地表示C1-C8烷基，可选部分氢化的C6-C10芳环，茚环或类似物; m表示1至3的整数; 每个独立地表示卤素原子，羟基，氰基，C1-C6烷基或类似物; n表示0至8的整数; 当X和Y或两个Y基附着在同一碳原子上时，它们可以结合形成C2-C6烷基lene基团。
• METHOD FOR PRODUCING OPTICALLY ACTIVE 2-ARYLPIPERAZINE DERIVATIVE
  申请人：Ohnuki Masatoshi

  公开号：US20100087643A1

  公开（公告）日：2010-04-08

  The objective of the present invention is to produce an optically active 2-arylpiperazine derivative useful as a synthetic intermediate for pharmaceutical products and agricultural chemicals from inexpensive and readily available starting material by an industrially practicable method. The objective can be accomplished by treating an optically active substituted aminodiol derivative produced from an optically active styrene oxide derivative with a sulfonating agent in the presence of a base, and then reacting an amine compound to obtain the 2-arylpiperazine derivative. Especially, an optically active 1-unsubstituted-2-arylpiperazine derivative can be produced by treating an optically active 1-allyl-2-arylpiperazine derivative with water in the presence of a transition metal catalyst for deallylation.

  本发明的目的是通过一种工业上可行的方法，从廉价且易得的起始材料中制备出一种光学活性的2-芳基哌嗪衍生物，该衍生物可作为制药产品和农药的合成中间体。该目标可以通过将光学活性苯乙烷氧化物衍生物产生的取代氨基二醇衍生物在碱的存在下与磺化剂处理，然后反应胺化合物以获得2-芳基哌嗪衍生物来实现。特别地，可以通过在过渡金属催化剂的存在下，将光学活性的1-烯丙基-2-芳基哌嗪衍生物在水的存在下进行去烯丙基化反应，来制备出光学活性的1-未取代-2-芳基哌嗪衍生物。
• 2,3,6-trisubstituted-4-pyrimidone derivatives
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2305651A1

  公开（公告）日：2011-04-06

  A pyrimidone derivative having tau protein kinase 1 inhibitory activity which is represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein Q represents CH or nitrogen atom; R represents a C1-C12 alkyl group; the ring of: represents piperazine ring or piperidine ring.

  一种具有 tau 蛋白激酶 1 抑制活性的嘧啶酮衍生物，由式 (I) 或其盐或其溶液或其水合物表示： 其中 Q 代表 CH 或氮原子；R 代表 C1-C12 烷基；环的： 代表哌嗪环或哌啶环。
• 2, 3, 6-TRISUBSTITUTED-4-PYRIMIDONE DERIVATIVES
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1608630A1

  公开（公告）日：2005-12-28