N-(4-methylphenyl)-6-[(4-phenylpiperazin-1-yl)methyl]-1,3,5-triazine-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-(4-methylphenyl)-6-[(4-phenylpiperazin-1-yl)methyl]-1,3,5-triazine-2,4-diamine
• 英文别名: 2-N-(4-methylphenyl)-6-[(4-phenylpiperazin-1-yl)methyl]-1,3,5-triazine-2,4-diamine
• 化学式: C₂₁H₂₅N₇
• mdl: MFCD03903891
• 分子量: 375.5
• InChiKey: DMIFRSNZEOKCMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  83.2
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Heteroaryl compounds and their use
  申请人：Minoryx Therapeutics S.L.

  公开号：US11174242B2

  公开（公告）日：2021-11-16

  The application is directed to compounds of formula (I): and their salts and solvates, wherein R1, R2, R3, A1, A2, A3, and n are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of a lysosomal storage disease, such as Gaucher's, and other diseases or disorders that are synucleinopathies.

  本申请涉及式（I）化合物：及其盐类和溶解物，其中 R1、R2、R3、A1、A2、A3 和 n 如说明书所述，还涉及其制备方法、包含这些化合物的药物组合物，以及将其用于治疗和/或预防溶酶体贮积疾病（如戈谢病）和属于突触核蛋白病的其他疾病或紊乱的用途。
• TRIAZINE DERIVATIVES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE
  申请人：Glucox Biotech AB

  公开号：EP2911667A1

  公开（公告）日：2015-09-02
• HETEROARYL COMPOUNDS AND THEIR USE
  申请人：Minoryx Therapeutics S.L.

  公开号：US20190337922A1

  公开（公告）日：2019-11-07

  The application is directed to compounds of formula (I): and their salts and solvates, wherein R 1 , R 2 , R 3 , A 1 , A 2 , A 3 , and n are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of a lysosomal storage disease, such as Gaucher's, and other diseases or disorders that are synucleinopathies.
• US9687490B2
  申请人：——

  公开号：US9687490B2

  公开（公告）日：2017-06-27
• [EN] TRIAZINE DERIVATIVES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE<br/>[FR] DÉRIVÉS DE TRIAZINE POUR LE TRAITEMENT DE CONDITIONS ASSOCIÉES À LA NICOTINAMIDE ADÉNINE DINUCLÉOTIDE PHOSPHATE OXYDASE
  申请人：GLUCOX BIOTECH AB

  公开号：WO2014064118A1

  公开（公告）日：2014-05-01

  A compound of formula (I) for use in the treatment of a condition or disorder associated with nicotinamide adenine dinucleotide phosphate oxidase.