3,3,11,11-tetramethyl-15-[4-(3,3,11,11-tetramethyl-1,5,9,13-tetraoxo-15-azadispiro[5.1.5.3]hexadec-15-yl)phenyl]-15-azadispiro-[5.1.5.3]hexadecane-1,5,9,13-tetrone | 1042730-88-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3,3,11,11-tetramethyl-15-[4-(3,3,11,11-tetramethyl-1,5,9,13-tetraoxo-15-azadispiro[5.1.5.3]hexadec-15-yl)phenyl]-15-azadispiro-[5.1.5.3]hexadecane-1,5,9,13-tetrone
• 英文别名: 3,3,11,11-Tetramethyl-15-[4-(3,3,11,11-tetramethyl-1,5,9,13-tetraoxo-15-azadispiro[5.1.58.36]hexadecan-15-yl)phenyl]-15-azadispiro[5.1.58.36]hexadecane-1,5,9,13-tetrone；3,3,11,11-tetramethyl-15-[4-(3,3,11,11-tetramethyl-1,5,9,13-tetraoxo-15-azadispiro[5.1.58.36]hexadecan-15-yl)phenyl]-15-azadispiro[5.1.58.36]hexadecane-1,5,9,13-tetrone
• CAS: 1042730-88-0
• 化学式: C₄₄H₅₆N₂O₈
• 分子量: 740.937
• InChiKey: GPDICYXWBXTOSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  54
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  143
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 5,5-二甲基-1,3-环己二酮 、 对苯二胺 以 乙醇 为溶剂， 以37%的产率得到3,3,11,11-tetramethyl-15-[4-(3,3,11,11-tetramethyl-1,5,9,13-tetraoxo-15-azadispiro[5.1.5.3]hexadec-15-yl)phenyl]-15-azadispiro-[5.1.5.3]hexadecane-1,5,9,13-tetrone
  参考文献：
  名称：

  A novel three-component reaction of anilines, formaldehyde and dimedone: simple synthesis of spirosubstituted piperidines

  摘要：

  A three-component condensation of anilines with dimedone and formaldehyde leads to the formation of 3,5-dispirosubstituted piperidines. This simple reaction can serve as a convenient source of 3,5-disubstituted piperidines as well as polyfunctional 3-spirofused piperidines. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.04.160

文献信息

• A novel three-component reaction of anilines, formaldehyde and dimedone: simple synthesis of spirosubstituted piperidines
  作者：Nikolas G. Kozlov、Aliaksei P. Kadutskii

  DOI：10.1016/j.tetlet.2008.04.160

  日期：2008.7

  A three-component condensation of anilines with dimedone and formaldehyde leads to the formation of 3,5-dispirosubstituted piperidines. This simple reaction can serve as a convenient source of 3,5-disubstituted piperidines as well as polyfunctional 3-spirofused piperidines. (c) 2008 Elsevier Ltd. All rights reserved.