1-{3-Methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl}piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-{3-Methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl}piperazine
• 英文别名: 3-methyl-6-piperazin-1-yl-[1,2,4]triazolo[4,3-b]pyridazine
• 化学式: C₁₀H₁₄N₆
• mdl: MFCD01471410
• 分子量: 218.26
• InChiKey: HPOZZZPWEOBLQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• HETEROCYCLIC COMPOUNDS AND USES THEREOF
  申请人：Ruan Fuqiang

  公开号：US20190308963A1

  公开（公告）日：2019-10-10

  In recognition of the unmet need to develop novel therapeutic agents, the present invention discloses a novel class of heterocycles as dual inhibitors of BRD4 and class I PI3Ks. The compounds claimed herein could be used alone or in combination therapies for the effective treatment of a wide range of age-related diseases, including cancer. The present invention also provides methods for preparing compounds of the invention thereto.

  为了开发新型治疗药物的未满足需求，本发明公开了一类新型杂环化合物，作为BRD4和I类PI3Ks的双重抑制剂。本文所述的化合物可单独使用或与其他药物联合治疗，有效治疗包括癌症在内的广泛的年龄相关疾病。本发明还提供了制备这些化合物的方法。
• Heterocyclic compounds and uses thereof
  申请人：Ruan Fuqiang

  公开号：US10442799B1

  公开（公告）日：2019-10-15

  In recognition of the unmet need to develop novel therapeutic agents, the present invention discloses a novel class of heterocycles as dual inhibitors of BRD4 and class I PI3Ks. The compounds claimed herein could be used alone or in combination therapies for the effective treatment of a wide range of age-related diseases, including cancer. The present invention also provides methods for preparing compounds of the invention thereto.

  鉴于开发新型治疗剂的需求尚未得到满足，本发明公开了一类新型杂环化合物，作为 BRD4 和 I 类 PI3K 的双重抑制剂。本发明所述化合物可单独使用或用于联合疗法，以有效治疗包括癌症在内的多种老年相关疾病。本发明还提供了制备本发明化合物的方法。