6-Methyl-2-(piperazin-1-yl)-3,4-dihydropyrimidin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-Methyl-2-(piperazin-1-yl)-3,4-dihydropyrimidin-4-one
• 英文别名: 4-methyl-2-piperazin-1-yl-1H-pyrimidin-6-one
• 化学式: C₉H₁₄N₄O
• 分子量: 194.23
• InChiKey: HMAVWOFXKXDEEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  56.7
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• HEPATITIS B VIRAL ASSEMBLY EFFECTORS
  申请人：Indiana University Research and Technology Corporation

  公开号：US20180099952A1

  公开（公告）日：2018-04-12

  Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.