1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-4-methylpiperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-4-methylpiperazine
• 英文别名: 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-4-methylpiperazine；1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-4-methylpiperazine
• 化学式: C₁₁H₁₃ClF₃N₃
• mdl: MFCD06243223
• 分子量: 279.693
• InChiKey: XWIBFPUIDAUBLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.545
• 拓扑面积：
  19.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Proline derivatives and use thereof as drugs
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP1950199A1

  公开（公告）日：2008-07-30

  The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.

  本发明旨在提供因具有 DPP-IV 抑制作用而具有治疗效果的化合物，并提供令人满意的药物产品。 本发明者发现，在式 (I) 所代表的脯氨酸的 γ 位上引入取代基的衍生物 其中各符号如说明书中所定义，具有强效的 DPP-IV 抑制活性，并通过提高稳定性完成了本发明。
• PESTICIDALLY ACTIVE 1,2,4-TRIAZOLE DERIVATIVES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：US20190161499A1

  公开（公告）日：2019-05-30

  The present invention relates to 1,2,4-triazole derivatives, to processes for preparing them, to intermediates for preparing them, to pesticidli, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising those derivatives and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.