2-{4-[1-(Propan-2-yl)piperidin-4-yl]piperazin-1-yl}ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-{4-[1-(Propan-2-yl)piperidin-4-yl]piperazin-1-yl}ethanol
• 英文别名: 2-[4-(1-propan-2-ylpiperidin-4-yl)piperazin-1-yl]ethanol
• 化学式: C₁₄H₂₉N₃O
• 分子量: 255.4
• InChiKey: GPCYVFIILGIAMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  30
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 2(1H)-QUINOLINONE DERIVATIVE
  申请人：TAISHO PHARMACEUTICAL CO., LTD.

  公开号：US20210070747A1

  公开（公告）日：2021-03-11

  Provided are: useful novel compounds that exhibit antibacterial activity based on their actions for inhibiting GyrB of DNA gyrase and ParE of topoisomerase IV; and 2(1H)-quinolinone derivatives represented by formula [1]: or pharmaceutically acceptable salts thereof.
• COMPOUNDS AND METHODS FOR TARGETING PATHOGENIC BLOOD VESSELS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20210147385A1

  公开（公告）日：2021-05-20

  The disclosure provides compounds, and compositions, including pharmaceutical compositions, kits that include the compounds, and methods of using (or administering) and making the compounds. The disclosure further provides compounds or compositions thereof for use in a method of modulating PLXDC1 (TEM7) and/or PLXDC2 or killing pathogenic blood vessles. The disclosure further provides compounds or compositions thereof for use in a method of treating a disease, disorder, or condition that is mediated, at least in part, by PEDF receptors or by angiogenesis.
• [EN] HETEROARYL DERIVATIVE, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE COMPONENT<br/>[FR] DÉRIVÉ HÉTÉROARYLE, SON PROCÉDÉ DE PRODUCTION ET COMPOSITION PHARMACEUTIQUE LE COMPRENANT EN TANT QUE CONSTITUANT EFFICACE<br/>[KO] 헤테로아릴 유도체, 이를 제조하는 방법, 및 이를 유효성분으로 포함하는 약학적 조성물
  申请人：VORONOI CO LTD

  公开号：WO2020190119A1

  公开（公告）日：2020-09-24

  6-(아이소옥사졸리딘-2-일)-N-페닐피리미딘-4-아민 유도체, 상기 화합물을 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물에 관한 것이고, 상기 화합물은 EGFR(epidermal growth factor receptor) 돌연변이, 또는 ERBB2 및 ERBB4 중 하나 이상의 야생형 또는 돌연변이에 대하여 높은 억제능을 나타내므로, 이들이 발현된 암의 치료에 유용하게 사용될 수 있으며, 특히, 폐암 세포주 증식 억제능이 우수한 바, 폐암의 치료에 유용하게 사용될 수 있다.