(2R)-2-[4-(4-methoxyphenyl)-8-methyl-2-oxochromen-7-yl]oxypropanoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: (2R)-2-[4-(4-methoxyphenyl)-8-methyl-2-oxochromen-7-yl]oxypropanoic acid
• 化学式: C₂₀H₁₈O₆
• 分子量: 354.4
• InChiKey: YWJDOKHHRVZPLV-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof for the treatment of cancer
  申请人：Lead Discovery Center GmbH

  公开号：US10703735B2

  公开（公告）日：2020-07-07

  The invention provides novel 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

  本发明提供了新型 4-苯基香豆素衍生物、其制备工艺及其作为治疗癌症的特异性线粒体 RNA 聚合酶抑制剂的用途。
• Neuraminidase Inhibitors and uses thereof
  申请人：Prince Alice

  公开号：US20090175805A1

  公开（公告）日：2009-07-09

  The invention is related to various methods for inhibiting or reducing biofilm formation, treating a biofilm production-related disorder, preventing biofilm formation, and screening for neuraminidase inhibitors. The invention also encompasses a mutant bacterial strain with a deleted neuraminidase gene.
• 4-PHENYL-COUMARIN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND USES THEREOF FOR THE TREATMENT OF CANCER
  申请人：Lead Discovery Center GmbH

  公开号：US20200031794A1

  公开（公告）日：2020-01-30

  The invention provides novel 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.
• [EN] NEURAMINIDASE INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE NEURAMINIDASE, ET LEURS UTILISATIONS
  申请人：UNIV COLUMBIA

  公开号：WO2008054475A2

  公开（公告）日：2008-05-08

  [EN] The invention is related to various methods for inhibiting or reducing biofilm formation, treating a biofilm production-related disorder, preventing biofilm formation, and screening for neuraminidase inhibitors. The invention also encompasses a mutant bacterial strain with a deleted neuraminidase gene.
  [FR] L'invention concerne divers procédés pour inhiber ou réduire une formation de biofilm, traiter un trouble lié à une production de biofilm, empêcher une formation de biofilm, et cribler des inhibiteurs de neuraminidase. L'invention comprend également une souche bactérienne mutante ayant un gène de neuraminidase supprimé.