6-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-N-(3-methylphenyl)-1,3,5-triazine-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-N-(3-methylphenyl)-1,3,5-triazine-2,4-diamine
• 英文别名: 6-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]-2-N-(3-methylphenyl)-1,3,5-triazine-2,4-diamine
• 化学式: C₂₂H₂₇N₇O
• mdl: MFCD06594922
• 分子量: 405.5
• InChiKey: YXSCUKBXVOHOLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  92.4
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Small molecule inhibitors of Ku70/80 and uses thereof
  申请人：ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

  公开号：US10308656B2

  公开（公告）日：2019-06-04

  Provided herein are methods for identifying and treating subjects having conditions involving aberrant Ku70/80 activity. In particular, the invention relates to small-molecules which function as inhibitors of Ku70/80 protein and the non-homologous end-joining (NHEJ) pathway, and their use as therapeutics for the treatment of cancer and other diseases.

  本发明提供了用于鉴定和治疗患有涉及 Ku70/80 活性异常的疾病的受试者的方法。特别是，本发明涉及作为 Ku70/80 蛋白和非同源末端连接（NHEJ）途径抑制剂的小分子，以及它们作为治疗癌症和其他疾病的疗法的用途。
• [EN] SMALL MOLECULE INHIBITORS OF KU70/80 AND USES THEREOF<br/>[FR] INHIBITEURS DE KU70/80 À PETITES MOLÉCULES ET UTILISATIONS ASSOCIÉES
  申请人：UNIV ARIZONA

  公开号：WO2017031116A1

  公开（公告）日：2017-02-23

  Provided herein are methods for identifying and treating subjects having conditions involving aberrant Ku70/80 activity. In particular, the invention relates to small-molecules which function as inhibitors of Ku70/80 protein and the non-homologous end-joining (NHEJ) pathway, and their use as therapeutics for the treatment of cancer and other diseases.