N-(3-morpholin-4-ylpropyl)-4-phenylpiperazine-1-carboxamide | 127571-19-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-(3-morpholin-4-ylpropyl)-4-phenylpiperazine-1-carboxamide
• CAS: 127571-19-1
• 化学式: C₁₈H₂₈N₄O₂
• 分子量: 332.446
• InChiKey: STBWHUWHLCJMHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  48
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-苯基哌嗪 、 N-(3-morpholin-4-ylpropyl)-4-phenylpiperazine-1-carboxamide 生成 4-Phenyl-piperazine-1-carboxylic acid (2-morpholin-4-yl-ethyl)-amide
  参考文献：
  名称：

  WALSH, DAVID A.;GREEN, JERRY B.;FRANZYSHEN, STEPHEN K.;NOLAN, JOSEPH C.;Y+, J. MED. CHEM., 33,(1990) N, C. 2028-2032

  摘要：

  DOI：
• 作为产物：
  描述：

  N-苯基哌嗪 、 N-(3-氯丙基)吗啉 生成 N-(3-morpholin-4-ylpropyl)-4-phenylpiperazine-1-carboxamide
  参考文献：
  名称：

  WALSH, DAVID A.;GREEN, JERRY B.;FRANZYSHEN, STEPHEN K.;NOLAN, JOSEPH C.;Y+, J. MED. CHEM., 33,(1990) N, C. 2028-2032

  摘要：

  DOI：

文献信息

• Synthesis and antiallergy activity of N-[2-(dimethylamino)ethyl]-4-aryl-1-piperazinecarboxamide derivatives
  作者：David A. Walsh、Jerry B. Green、Stephen K. Franzyshen、Joseph C. Nolan、John M. Yanni

  DOI：10.1021/jm00169a037

  日期：1990.7

  A series of N-[2-(dimethylamino)ethyl]-4-aryl-1-piperazinecarboxamides was synthesized and evaluated for antiallergy activity. Several derivatives had activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity, but no derivative tested had activity at 10 mg/kg in the guinea pig anaphylaxis (GPA) assay. One analogue, N-[2-(dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide , had an IC50 = 310 nM for inhibition of tritiated mepyramine binding to H1 histaminic receptors isolated from guinea pig cerebral cortex.
• WALSH, DAVID A.;GREEN, JERRY B.;FRANZYSHEN, STEPHEN K.;NOLAN, JOSEPH C.;Y+, J. MED. CHEM., 33,(1990) N, C. 2028-2032
  作者：WALSH, DAVID A.、GREEN, JERRY B.、FRANZYSHEN, STEPHEN K.、NOLAN, JOSEPH C.、Y+

  DOI：——

  日期：——