4-N-[(4-ethylphenyl)methyl]-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-N-[(4-ethylphenyl)methyl]-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
• 化学式: C₁₈H₂₆N₆
• 分子量: 326.4
• InChiKey: UCPQTRBTYSYCLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  70.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] HISTAMINE 4 RECEPTOR PARTIAL AGONISTS, INVERSE AGONISTS OR ANTAGONISTS FOR USE|IN TREATING NON-AUTOIMMUNE UVEITIS<br/>[FR] AGONISTES PARTIELS, AGONISTES INVERSES OU ANTAGONISTES DU RÉCEPTEUR DE L'HISTAMINE 4 DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE L'UVÉITE NON AUTO-IMMUNE
  申请人：UCL BUSINESS PLC

  公开号：WO2014033480A1

  公开（公告）日：2014-03-06

  The invention provides a compound which is a histamine 4 receptor antagonist, partial agonist or inverse agonist, for use in the treatment of non-autoimmune uveitis. The compound preferably has a structural core comprising a substituted pyrimidine group, such as an aminopyrimidine, diaminopyrimidine or triaminopyrimidine group, a thienopyrimidine, a furopyrimidine, a benzimidazole, an aryl or heteroaryl-fused pyrimidine, an indole, a bicyclic heteroaryl-substituted imidazole or a quinazoline group.