[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoyl-(5-aminopentyl)amino] 2,2,2-trifluoroacetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: [5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoyl-(5-aminopentyl)amino] 2,2,2-trifluoroacetate
• 化学式: C₁₇H₂₇F₃N₄O₄S
• 分子量: 440.5
• InChiKey: GUCOLBVZQDOMHE-OBJOEFQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  29
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  139
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Anti-transglutaminase 2 antibodies
  申请人：MEDICAL RESEARCH COUNCIL TECHNOLOGY

  公开号：US10005846B2

  公开（公告）日：2018-06-26

  The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.

  本发明提供了可选择性地与转谷氨酰胺酶 2 型（TG2）核心区域内的表位结合的抗体及其抗原结合片段。本发明还提供了 TG2 核心内的新表位。本发明提供了人TG2抑制性抗体及其用途，特别是在医学方面，例如在治疗和/或诊断包括乳糜泻、瘢痕、纤维化相关疾病、神经退行性疾病/神经系统疾病和癌症等疾病方面。
• ANTI -TRANSGLUTAMINASE 2 ANTIBODIES
  申请人：Medical Research Council Technology

  公开号：EP2855530A1

  公开（公告）日：2015-04-08
• ANTI-TRANSGLUTAMINASE 2 ANTIBODIES
  申请人：LifeArc

  公开号：EP2855530B1

  公开（公告）日：2019-05-01
• Anti-Transglutaminase 2 Antibodies
  申请人：LIFEARC

  公开号：US20180355060A1

  公开（公告）日：2018-12-13

  The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.
• [EN] ANTI -TRANSGLUTAMINASE 2 ANTIBODIES<br/>[FR] ANTICORPS ANTI-TRANSGLUTAMINASE 2
  申请人：MEDICAL RES COUNCIL TECHNOLOGY

  公开号：WO2013175229A1

  公开（公告）日：2013-11-28

  The invention provides antibodies and antigen-binding fragments thereof that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). Novel epitopes within the TG2 core are provided. The invention provides human TG2 inhibitory antibodies and uses thereof, particularly in medicine, for example in the treatment and/or diagnosis of conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.