(RS)-6-{[7-({4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]piperazin-1-yl}carbonyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl]amino}-1,3-benzothiazol-2(3H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (RS)-6-{[7-({4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]piperazin-1-yl}carbonyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl]amino}-1,3-benzothiazol-2(3H)-one
• 英文别名: 6-[[7-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazine-1-carbonyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]amino]-3H-1,3-benzothiazol-2-one
• 化学式: C₂₈H₃₁N₇O₃S₂
• 分子量: 577.731
• InChiKey: DKKJMIOJGFUQJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  40
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  164
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] SUBSTITUTED BENZOTHIENOPYRIMIDINES<br/>[FR] BENZOTHIENOPYRIMIDINES SUBSTITUÉES
  申请人：BAYER PHARMA AG

  公开号：WO2013174735A1

  公开（公告）日：2013-11-28

  The present invention relates to substituted benzothienopyrimidine compounds of general formula I: in which R1a, R1b, R2a, R2b, and R2c are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及一般式I的取代苯并噻吡嘧啶化合物：其中R1a、R1b、R2a、R2b和R2c如所述和定义，在此处，制备所述化合物的方法，用于制备所述化合物的中间化合物，包含所述化合物的药物组合物和组合物，以及使用所述化合物制造用于治疗或预防疾病的药物组合物，特别是治疗或预防过度增殖和/或血管生成障碍的疾病，作为唯一药剂或与其他活性成分结合使用。
• Substituted Benzothienopyrimidines
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20150152121A1

  公开（公告）日：2015-06-04

  The present invention relates to substituted benzothienopyrimidine compounds of general formula I: in which R 1a , R 1b , R 2a , R 2b , and R 2c are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及一般式I的取代苯并噻吩嘧啶化合物，其中R1a，R1b，R2a，R2b和R2c的定义如本文所述，以及制备该化合物的方法，有用于制备该化合物的中间体化合物，包括该化合物的制药组合物和组合物，以及用于制造治疗或预防疾病的制药组合物的使用，特别是用作单一药物或与其他活性成分组合使用，用于治疗或预防过度增殖和/或血管生成障碍的疾病。
• SUBSTITUTED BENZOTHIENOPYRIMIDINES
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP2852595A1

  公开（公告）日：2015-04-01
• US9296757B2
  申请人：——

  公开号：US9296757B2

  公开（公告）日：2016-03-29