(2S,5R)-1-tert-butyl-2,5-dimethylpiperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (2S,5R)-1-tert-butyl-2,5-dimethylpiperazine
• 化学式: C₁₀H₂₂N₂
• 分子量: 170.3
• InChiKey: XZTRWBUPYDQHLN-BDAKNGLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Substituted quinazoline compounds and methods of use
  申请人：ARAXES PHARMA LLC

  公开号：US10822312B2

  公开（公告）日：2020-11-03

  The present disclosure provides inhibitors of Ras protein of Formula (I-A): Also disclosed are methods to modulate the activity of Ras protein and methods of treatment of disorders mediated by Ras protein with compounds of Formula (I-A).

  本公开提供了式 (I-A) 的 Ras 蛋白抑制剂： 还公开了用式（I-A）化合物调节 Ras 蛋白活性的方法和治疗由 Ras 蛋白介导的疾病的方法。
• TETRAHYDROPYRAZOLOPYRIMIDINE COMPOUNDS
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2855476A2

  公开（公告）日：2015-04-08
• SUBSTITUTED QUINAZOLINE COMPOUNDS AND METHODS OF USE
  申请人：ARAXES PHARMA LLC

  公开号：US20190127336A1

  公开（公告）日：2019-05-02

  The present disclosure provides inhibitors of Ras protein. Also disclosed are methods to modulate the activity of Ras protein and methods of treatment of disorders mediated by Ras protein.
• [EN] TETRAHYDROPYRAZOLOPYRIMIDINE COMPOUNDS<br/>[FR] COMPOSÉS TÉTRAHYDROPYRAZOLOPYRIMIDINES
  申请人：EISAI R&D MAN CO LTD

  公开号：WO2013181579A2

  公开（公告）日：2013-12-05

  Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis