Prop-2-enyl 5-amino-1-benzofuran-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: Prop-2-enyl 5-amino-1-benzofuran-2-carboxylate
• 英文别名: prop-2-enyl 5-amino-1-benzofuran-2-carboxylate
• 化学式: C₁₂H₁₁NO₃
• 分子量: 217.22
• InChiKey: XDPDMTFJMUPHEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] IMPROVED PROCESS FOR PREPARING BENZOFURAN-2-CARBOXAMIDE DERIVATIVES<br/>[FR] PROCÉDÉ AMÉLIORÉ DE PRÉPARATION DE DÉRIVÉS DE BENZOFURAN-2-CARBOXAMIDE
  申请人：SYMED LABS LTD

  公开号：WO2014006637A2

  公开（公告）日：2014-01-09

  Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of benzofuran-2-carboxamide derivatives and their intermediates, or a pharmaceutically acceptable salt thereof, in high yield and purity. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of vilazodone or a pharmaceutically acceptable salt thereof in high yield and purity. Provided also herein is an improved and commercially viable process for the preparation of 3-(4-hydroxybutyl)-1H-indole-5-carbonitrile, in high yield and purity, using novel intermediate compound 3-(4-hydroxybutyryl)-1H-indole-5-carbonitrile.

  本文提供了一种新颖、商业可行和工业优越的过程，用于制备苯并呋喃-2-羧酰胺衍生物及其中间体或其药学上可接受的盐，收率和纯度高。特别提供了一种新颖、商业可行和工业优越的过程，用于制备维拉唑酮或其药学上可接受的盐，收率和纯度高。本文还提供了一种改进的、商业可行的过程，用于使用新颖的中间体化合物3-(4-羟基丁酰基)-1H-吲哚-5-碳腈，高收率和高纯度地制备3-(4-羟基丁基)-1H-吲哚-5-碳腈。
• IMPROVED PROCESS FOR PREPARING BENZOFURAN-2-CARBOXAMIDE DERIVATIVES
  申请人：SYMED LABS LIMITED

  公开号：US20150322030A1

  公开（公告）日：2015-11-12

  Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of benzofuran-2-carboxamide derivatives and their intermediates, or a pharmaceutically acceptable salt thereof, in high yield and purity. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of vilazodone or a pharmaceutically acceptable salt thereof in high yield and purity. Provided also herein is an improved and commercially viable process for the preparation of 3-(4-hydroxybutyl)-1H-indole-5-carbonitrile, in high yield and purity, using novel intermediate compound 3-(4-hydroxybutyryl)-1H-indole-5-carbonitrile.

  本文提供了一种新的、商业上可行且具有工业优势的方法，用于高产率和高纯度制备苯并呋喃-2-羧酰胺衍生物及其中间体，或其药学上可接受的盐。特别提供了一种新的、商业上可行且具有工业优势的方法，用于高产率和高纯度制备维拉唑酮或其药学上可接受的盐。本文还提供了一种改进的、商业上可行的方法，使用新的中间体化合物3-(4-羟基丁酰基)-1H-吲哚-5-碳腈，高产率和高纯度地制备3-(4-羟基丁基)-1H-吲哚-5-碳腈。
• PROCESS FOR PREPARING BENZOFURAN-2-CARBOXAMIDE DERIVATIVES
  申请人：SYMED LABS LIMITED

  公开号：US20170267655A1

  公开（公告）日：2017-09-21

  Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of benzofuran-2-carboxamide derivatives and their intermediates, or a pharmaceutically acceptable salt thereof, in high yield and purity. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of vilazodone or a pharmaceutically acceptable salt thereof in high yield and purity. Provided also herein is an improved and commercially viable process for the preparation of 3-(4-hydroxybutyl)-1H-indole-5-carbonitrile, in high yield and purity, using novel intermediate compound 3-(4-hydroxybutyryl)-1H-indole-5-carbonitrile.

  本文提供了一种新颖、商业可行和工业优势的过程，用于制备苯并呋喃-2-羧酰胺衍生物及其中间体，或其药用可接受盐，产率和纯度高。本文特别提供了一种新颖、商业可行和工业优势的过程，用于制备维拉唑酮或其药用可接受盐，产率和纯度高。本文还提供了一种改进的、商业可行的过程，用于利用新的中间化合物3-(4-羟基丁酰基)-1H-吲哚-5-碳腈，高产高纯地制备3-(4-羟基丁基)-1H-吲哚-5-碳腈。
• US9315456B2
  申请人：——

  公开号：US9315456B2

  公开（公告）日：2016-04-19
• US9399630B2
  申请人：——

  公开号：US9399630B2

  公开（公告）日：2016-07-26