3-Oxo-3-piperazin-4-ium-1-ylpropanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-Oxo-3-piperazin-4-ium-1-ylpropanoate
• 化学式: C7H12N2O3
• 分子量: 172.18
• InChiKey: DLISZJCQUBTZTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  77
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Substituted heterocyclic compounds for treating multidrug resistance
  申请人：The Procter & Gamble Company

  公开号：US20040132722A1

  公开（公告）日：2004-07-08

  Substituted heterocyclic compounds for treating multidrug resistance are disclosed. Compositions and methods of use for the substituted heterocyclic compounds are disclosed. Suitable substituted heterocyclic compounds include: 1

  公开了用于治疗多药耐药的取代杂环化合物。公开了用于取代杂环化合物的组成物和使用方法。适当的取代杂环化合物包括：1。
• SUBSTITUTED PIPERAZINE COMPOUNDS OPTIONALLY CONTAINING A QUINOLYL MOIETY FOR TREATING MULTIDRUG RESISTANCE
  申请人：——

  公开号：US20020123498A1

  公开（公告）日：2002-09-05

  Substituted heterocyclic compounds for treating multidrug resistance are disclosed. Compositions and methods of use for the substituted heterocyclic compounds are disclosed. Suitable substituted heterocyclic compounds include: 1

  本发明公开了用于治疗多药耐药的取代杂环化合物。本发明公开了用于取代杂环化合物的组成物和使用方法。适用于取代杂环化合物的合适化合物包括：1
• DERIVATIVE BASED ON COMMON ANEMARRHENAE RHIZOME SARSASAPOGENIN STRUCTURE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
  申请人：Phytovent Biopharma

  公开号：EP3858849A1

  公开（公告）日：2021-08-04

  The present invention relates to a derivative of sarsasapogenin having a structure of formula I, The present invention also provides a pharmaceutical composition of the aforementioned derivative of sarsasapogenin and use thereof. By systematic modification and derivatization of sarsasapogenin structure in combination with inhibitory activity assays on tumor cells, the inventor surprisingly found that many derivative compounds have excellent inhibitory activity on tumor cells, particularly high inhibitory activity on the growth of various brain tumor cells, having potential wide application and tremendous value in treating various cancers, making up for the deficiency of modified derivatives of sarsasapogenin in the prior art and having important scientific and commercial application value.

  本发明涉及一种具有式 I 结构的菝葜皂苷元衍生物、 本发明还提供了上述菝葜皂苷元衍生物的药物组合物及其用途。通过对菝葜皂苷元结构的系统修饰和衍生化，结合对肿瘤细胞的抑制活性实验，本发明人惊喜地发现，许多衍生化合物对肿瘤细胞具有极好的抑制活性，特别是对各种脑肿瘤细胞的生长具有很高的抑制活性，在治疗各种癌症方面具有潜在的广泛应用和巨大价值，弥补了现有技术中菝葜皂苷元修饰衍生物的不足，具有重要的科学和商业应用价值。
• SUBSTITUTED HETEROCYCLIC COMPOUNDS FOR TREATING MULTIDRUG RESISTANCE
  申请人：H. Lee Moffitt Cancer Center & Research Institute, Inc.

  公开号：EP1326840B1

  公开（公告）日：2012-04-11
• DERIVATIVE OF SARSASAPOGENIN, PHARMACEUTICAL COMPOSITION AND USE THEREOF
  申请人：Phytovent Biopharma

  公开号：US20220033436A1

  公开（公告）日：2022-02-03

  A derivative of sarsasapogenin is provided having a structure of formula I, A pharmaceutical composition of the aforementioned derivative of sarsasapogenin and use thereof are also provided. By systematic modification and derivatization of sarsasapogenin structure in combination with inhibitory activity assays on tumor cells, many derivative compounds are provided that have excellent inhibitory activity on tumor cells, particularly high inhibitory activity on the growth of various brain tumor cells, having potential wide application and tremendous value in treating various cancers.