4-[2-(2-Hydroxyethoxy)ethyl]-3-[[(2,2,2-trifluoroacetyl)amino]methyl]piperazine-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-[2-(2-Hydroxyethoxy)ethyl]-3-[[(2,2,2-trifluoroacetyl)amino]methyl]piperazine-1-carboxylic acid
• 英文别名: 4-[2-(2-hydroxyethoxy)ethyl]-3-[[(2,2,2-trifluoroacetyl)amino]methyl]piperazine-1-carboxylic acid
• 化学式: C₁₂H₂₀F₃N₃O₅
• 分子量: 343.3
• InChiKey: AHQKUVIJTQDSDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  102
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• HAPTENS OF QUETIAPINE
  申请人：Ortho-Clinical Diagnostics, Inc.

  公开号：US20140221616A1

  公开（公告）日：2014-08-07

  The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from quetiapine. The invention also relates to conjugates of a quetiapine hapten and a protein.

  本发明涉及式I的化合物，其中R1、R2和R3在说明书中定义，用于合成源自喹硫平的新型共轭物和免疫原。本发明还涉及喹硫平半抗原和蛋白质的共轭物。
• Antibodies to quetiapine haptens and use thereof
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：US10465013B2

  公开（公告）日：2019-11-05

  Disclosed is an antibody which binds to quetiapine, which can be used to detect quetiapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of quetiapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

  本发明公开了一种与喹硫平结合的抗体，可用于检测样品中的喹硫平，如竞争性免疫分析法。该抗体可用于横向流动检测装置，进行喹硫平的床旁检测，包括在单个横向流动检测装置中对阿立哌唑、奥氮平、喹硫平和利培酮进行多重检测。
• HAPTENS OF QUETIAPINE FOR USE IN IMMUNOASSAYS
  申请人：Janssen Pharmaceutica NV

  公开号：EP2888257B1

  公开（公告）日：2017-08-02
• ANTIBODIES TO QUETIAPINE HAPTENS AND USE THEREOF
  申请人：Ortho-Clinical Diagnostics, Inc.

  公开号：EP2888286A1

  公开（公告）日：2015-07-01
• US9304126B2
  申请人：——

  公开号：US9304126B2

  公开（公告）日：2016-04-05