2-[5-[1-[6-[2-[3-[1-(4-amino-6,7-dimethoxyquinazolin-2-yl)-4-(3-phenylpropanoyl)piperazin-2-yl]phenoxy]ethylamino]-6-oxohexyl]-3,3-dimethyl-5-sulfoindol-1-ium-2-yl]penta-2,4-dienylidene]-1-ethyl-3,3-dimethylindole-5-sulfonic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[5-[1-[6-[2-[3-[1-(4-amino-6,7-dimethoxyquinazolin-2-yl)-4-(3-phenylpropanoyl)piperazin-2-yl]phenoxy]ethylamino]-6-oxohexyl]-3,3-dimethyl-5-sulfoindol-1-ium-2-yl]penta-2,4-dienylidene]-1-ethyl-3,3-dimethylindole-5-sulfonic acid
• 化学式: C64H75N8O11S2+
• 分子量: 1196.5
• InChiKey: FDJLKOUVAXNRQW-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  85
• 可旋转键数：
  23
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  264
• 氢给体数：
  4
• 氢受体数：
  16

文献信息

• COMPLEMENT PATHWAY MODULATORS AND USES THEREOF
  申请人：Novartis AG

  公开号：EP2855456B1

  公开（公告）日：2017-03-29
• 2-(1H-INDOL-4-YLMETHYL)-3H-IMIDAZO[4,5-B]PYRIDINE-6-CARBONITRILE DERIVATIVES AS COMPLEMENT FACTOR B INHIBITORS USEFUL FOR THE TREATMENT OF OPHTHALMIC DISEASES
  申请人：Novartis AG

  公开号：EP2970269B1

  公开（公告）日：2017-04-19
• PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS
  申请人：Novartis AG

  公开号：EP3022192B1

  公开（公告）日：2017-10-11
• [EN] COMPLEMENT PATHWAY MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DES VOIES DU COMPLÉMENT ET LEURS UTILISATIONS
  申请人：NOVARTIS AG

  公开号：WO2013164802A1

  公开（公告）日：2013-11-07

  The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.