1-(2-Chloro-5-methylphenyl)-4-methylpiperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(2-Chloro-5-methylphenyl)-4-methylpiperazine
• 英文别名: 1-(2-chloro-5-methylphenyl)-4-methylpiperazine
• 化学式: C₁₂H₁₇ClN₂
• 分子量: 224.73
• InChiKey: HVOQQZVCGHTLKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS<br/>[FR] COMPOSÉS ET PROCÉDÉS DE TRAITEMENT D'INFECTIONS MICROBIENNES GASTRO-INTESTINALES DE MAMMIFÈRE
  申请人：UNIV BRANDEIS

  公开号：WO2014028931A2

  公开（公告）日：2014-02-20

  Disclosed are compounds and pharmaceutically acceptable salts thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound selectively inhibits a parasitic IMPDH versus a host IMPDH. Also disclosed are pharmaceutical compositions comprising one or more compounds of the invention. Related methods of treating various parasitic and bacterial infections in mammals are disclosed. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.