1,1-Dimethylethyl 4-(5-bromo-3-methoxy-2-pyridinyl)-1-piperazinecarboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,1-Dimethylethyl 4-(5-bromo-3-methoxy-2-pyridinyl)-1-piperazinecarboxylate
• 英文别名: tert-butyl 4-(5-bromo-3-methoxypyridin-2-yl)piperazine-1-carboxylate
• 化学式: C₁₅H₂₂BrN₃O₃
• 分子量: 372.26
• InChiKey: HSLCWVWDPFGOJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  54.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE 3-(PYRAZOLYL)-1H-PYRROLO[2,3-B]PYRIDINE EN TANT QU'INHIBITEURS DE KINASE
  申请人：AURIGENE DISCOVERY TECH LTD

  公开号：WO2014006554A1

  公开（公告）日：2014-01-09

  The present application relates to novel 3-(pyrazolyl)-lH-pyrrolo[2,3-b]pyridine derivatives of formula (I), as protein kinase inhibitors. The invention particularly relates to compounds of formula (I), preparation of compounds and pharmaceutical compositions thereof. The invention further relates to pharmaceutically acceptable salts and compositions comprising the said novel 3-(pyrazolyl)-lH-pyrrolo[2,3-b]pyridine derivatives and their use in the treatment of various disorders.

  本申请涉及一种新型的3-(吡唑基)-lH-吡咯并[2,3-b]吡啶衍生物，其化学式为(I)，作为蛋白激酶抑制剂。该发明特别涉及化合物的化学式(I)、化合物的制备以及其药物组成。该发明还涉及药用可接受的盐和组合物，包括所述新型的3-(吡唑基)-lH-吡咯并[2,3-b]吡啶衍生物及其在治疗各种疾病中的应用。
• 3-(Pyrazolyl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors
  申请人：Aurigene Discovery Technologies Limited

  公开号：US20150336949A1

  公开（公告）日：2015-11-26

  The present application relates to novel 3-(pyrazolyl)-1H-pyrrolo[2,3-b]pyridine derivatives of formula (I), as protein kinase inhibitors. The invention particularly relates to compounds of formula (I), preparation of compounds and pharmaceutical compositions thereof. The invention further relates to pharmaceutically acceptable salts and compositions comprising the said novel 3-(pyrazolyl)-1H-pyrrolo[2,3-b]pyridine derivatives and their use in the treatment of various disorders.

  本申请涉及一种新型的3-(吡唑基)-1H-吡咯[2,3-b]吡啶衍生物，其为蛋白激酶抑制剂。本发明特别涉及化合物(I)的制备、化合物的制备和制药组合物。本发明还涉及药学上可接受的盐和组成物，包括所述新型3-(吡唑基)-1H-吡咯[2,3-b]吡啶衍生物及其在治疗各种疾病中的用途。
• SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR
  申请人：CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD

  公开号：US20160002205A1

  公开（公告）日：2016-01-07

  Disclosed are a 2 -aminopyridine derivative having protein kinase inhibition activity, preparation method and pharmaceutical composition thereof. Also disclosed are uses of the compound and the pharmaceutical composition thereof in the preparation of drugs for treating and/or preventing protein kinase-related diseases.

  本发明公开了具有蛋白激酶抑制活性的a2-氨基吡啶衍生物、其制备方法和药物组成物。本发明还公开了该化合物和药物组成物在制备用于治疗和/或预防蛋白激酶相关疾病的药物中的用途。
• US9353107B2
  申请人：——

  公开号：US9353107B2

  公开（公告）日：2016-05-31