[[[[(2R,4S,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxy-methylidene-lambda5-phosphanyl]oxy-hydroxy-methylidene-lambda5-phosphanyl]methyl-hydroxy-methylidene-lambda5-phosphanyl] [(2R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphite

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: [[[[(2R,4S,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxy-methylidene-lambda5-phosphanyl]oxy-hydroxy-methylidene-lambda5-phosphanyl]methyl-hydroxy-methylidene-lambda5-phosphanyl] [(2R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphite
• 英文别名: [[[[(2R,4S,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxy-methylidene-λ5-phosphanyl]oxy-hydroxy-methylidene-λ5-phosphanyl]methyl-hydroxy-methylidene-λ5-phosphanyl] [(2R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphite
• 化学式: C₂₄H₃₆N₁₀O₁₄P₄
• 分子量: 812.5
• InChiKey: QIYNCZFKXVQSLR-SZRQWEAASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  52
• 可旋转键数：
  14
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  357
• 氢给体数：
  10
• 氢受体数：
  22

文献信息

• [EN] DINUCELOSIDE POLYPHOSPHATES FOR THE TREATMENT OF PAIN<br/>[FR] DINUCLÉOSIDE POLYPHOSPHATES POUR LE TRAITEMENT DE LA DOULEUR
  申请人：GLOBALACORN LTD

  公开号：WO2013175231A1

  公开（公告）日：2013-11-28

  The invention provides a dinucleoside polyphosphate analogue, or a pharmaceutically acceptable salt thereof, for use in the inhibition (or down-regulation) of a pain, via a transducing ATP -gated P2X3 receptor, often by means of high-affinity desensitisation (HAD) mechanism.