N-methylpiperazinium acetate | 32571-99-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-methylpiperazinium acetate
• 英文别名: N-methyl-piperazine acetic acid；1-Meth-ylpiperazinium acetate；1-methylpiperazin-1-ium;acetate
• CAS: 32571-99-6
• 化学式: C₂H₄O₂*C₅H₁₂N₂
• 分子量: 160.216
• InChiKey: RNMPQGAJPLFVRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.39
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5,6-二氢-4H-噻吩并[2,3-b]噻喃-4-酮 、 N-methylpiperazinium acetate 在 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 反应 120.0h， 以77%的产率得到1-(5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl)-4-methylpiperazine
  参考文献：
  名称：

  New structures able to prevent the inhibition by hydroxyl radicals of glutamate transport in cultured astrocytes

  摘要：

  4,5,6,7-Tetrahydro-benzothiophen-7-ylamines, 4,5,6,7-tetrahydro-benzothiophen-4-ylamines and 5,6-dihydro-4H-thieno[2,3-b] thiopyran-4-ylamines were designed, synthesized, and tested as OH. radical scavengers. Most of them displayed chemical scavenging properties better than or in the same range as salicylic acid. Moreover, some compounds were able to protect in vitro the astroglial glutamate transporters against inhibitory action of radicals promoted by xanthine/xanthine oxidase. Thus, such compounds might be useful for lowering the large amounts of excitotoxic glutamate liberated during acute CNS diseases: they might protect the glutamate reuptake in astrocytes from the inhibitory action due to radicals co-liberated with glutamate. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80011-7

文献信息

• Mixtures of isobarically labeled analytes and fragments ions derived therefrom
  申请人：Pappin J. C. Darryl

  公开号：US20050147985A1

  公开（公告）日：2005-07-07

  This invention pertains to mixtures of isobarically labeled analytes and fragment ions thereof.

  这项发明涉及等压标记的分析物混合物及其碎片离子。
• Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid
  作者：Lucie Borkova、Richard Adamek、Petr Kalina、Pavel Drašar、Petr Dzubak、Sona Gurska、Jiri Rehulka、Marian Hajduch、Milan Urban、Jan Sarek

  DOI：10.1002/cmdc.201600626

  日期：2017.3.7

  2‐Bromoallobetulone (2 b) methyl 2‐bromobetulonate (3 b), 2‐bromooleanonic acid (5 b), and 2‐thiocyanooleanonic acid (5 c) were best, with IC50 values less than 10 μm against CCRF‐CEM cells (e.g., 3 b: IC50=2.9 μm) as well as 2′‐(diethylamino)olean‐12(13)‐eno[2,3‐d]thiazole‐28‐oic acid (5 f, IC50=9.7 μm) and 2′‐(N‐methylpiperazino)olean‐12(13)‐eno[2,3‐d]thiazole‐28‐oic acid (5 k, IC50=11.4 μm). Compound 5 c leads to

  分别从别洛酮，牛磺酸甲基苯磺酸盐，油酸甲酯和齐墩果酸中制备了41种新的三萜类化合物，以研究它们对癌细胞的影响。每个3-氧杂环丁烯在C2处溴化，并用硫氰酸酯取代；随后用适当的铵盐环化，得到N-取代的噻唑。测试了所有化合物对8种癌细胞系和2种非癌性成纤维细胞的体外细胞毒活性。最好的2-Bromoallobetulone（2 b）2-Bromobetulonate（3 b），2-Bromooleanonic acid（5 b）和2-thiocyanooleanonic acid（5 c），相对于CCRF-CEM ，IC 50值小于10μm电池（例如3 b：IC50 = 2.9μ米）以及2' - （二乙氨基）齐墩果-12（13）-eno [2,3- d ]噻唑-28-酸（5 F，IC 50 = 9.7μ米）和2' - （ñ -methylpiperazino）齐墩果-12（13）-eno [2,3-
• Isobarically labeled analytes and fragment ions derived therefrom
  申请人：Pappin Darryl J.C.

  公开号：US20050148087A1

  公开（公告）日：2005-07-07

  This invention pertains to isobarically labeled analytes and fragment ions thereof.

  这项发明涉及等压标记的分析物及其碎片离子。
• Thienopyrimidine compounds as protein tyrosine kinase inhibitors
  申请人：Caferro R. Thomas

  公开号：US20050009845A1

  公开（公告）日：2005-01-13

  The present invention relates to thienopyrmidine compounds of formula (I) (one of A 1 and A 2 is S and the other is CH), salts thereof, as well as use and preparation of the same. These compounds are inhibitors of various protein tyrosine kinases (PTKs) of the ErbB family and consequently are useful in the treatment of disorders mediated by aberrant activity of such kinases.

  本发明涉及式（I）的噻唑吡啶化合物（其中A1和A2中的一个是S，另一个是CH），其盐，以及其用途和制备方法。这些化合物是ErbB家族的各种蛋白酪氨酸激酶（PTKs）的抑制剂，因此在治疗由这些激酶异常活性介导的疾病方面是有用的。
• ISOBARICALLY LABELED ANALYTES AND FRAGMENT IONS DERIVED THEREFROM
  申请人：PAPPIN Darryl J.C.

  公开号：US20100129842A1

  公开（公告）日：2010-05-27

  This invention pertains to isobarically labeled analytes and fragment ions thereof.

  这项发明涉及等压标记的分析物及其碎片离子。