5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-(methylamino)ethyl]pentanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-(methylamino)ethyl]pentanamide
• 化学式: C₁₃H₂₄N₄O₂S
• 分子量: 300.42
• InChiKey: QMVLVYYHAANPHD-NHCYSSNCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  108
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• lanthanide toolbox for multi-modal, non-invasive tumor specific theranostic prodrugs
  申请人：Hong Kong Baptist University

  公开号：US20180078564A1

  公开（公告）日：2018-03-22

  The present disclosure relates to theranostic prodrugs with responsive signals in-vitro or in-vivo and uses thereof. It also relates to synthesized europium complexes for evaluating the binding with integrin αvβ3.

  本公开涉及具有体外或体内响应信号的治疗诊断前药及其用途。它还涉及合成的铕配合物，用于评估与整合素αvβ3的结合。
• [EN] DERIVATIVES OF DOCOSAHEXAENOYLETHANOLAMIDE AND USES THEREOF<br/>[FR] DÉRIVÉS DE DOCOSAHEXAÉNOYLÉTHANOLAMIDE ET SES UTILISATIONS
  申请人：US HEALTH

  公开号：WO2013158302A1

  公开（公告）日：2013-10-24

  The invention provides derivatives of DEA which have increased potency and hydrolysis resistance as compared to DEA, and compositions thereof, as well as methods of using these derivatives to promote neurogenesis, neurite growth and/or length, and/or promote synaptogenesis.

  本发明提供了与DEA相比具有更高效能和更强水解抗性的DEA衍生物及其组成物，以及使用这些衍生物促进神经发生、神经突起生长和/或长度，以及/或促进突触形成的方法。
• Lanthanide toolbox for multi-modal, non-invasive tumor specific theranostic prodrugs
  申请人：Hong Kong Baptist University

  公开号：US10183027B2

  公开（公告）日：2019-01-22

  The present disclosure relates to theranostic prodrugs with responsive signals in-vitro or in-vivo and uses thereof. It also relates to synthesized europium complexes for evaluating the binding with integrin αvβ3.

  本公开涉及具有体外或体内响应信号的治疗原药及其用途。它还涉及用于评估与整合素 αvβ3 结合情况的合成铕复合物。
• DERIVATIVES OF DOCOSAHEXAENOYLETHANOLAMIDE AND USES THEREOF
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Serv

  公开号：US20150031878A1

  公开（公告）日：2015-01-29

  The invention provides derivatives of DEA which have increased potency and hydrolysis resistance as compared to DEA, and compositions thereof, as well as methods of using these derivatives to promote neurogenesis, neurite growth and/or length, and/or promote synaptogenesis.
• US9422308B2
  申请人：——

  公开号：US9422308B2

  公开（公告）日：2016-08-23