(2R)-2-hydroxy-N-[3-hydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadecan-2-yl]tetracosanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: (2R)-2-hydroxy-N-[3-hydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadecan-2-yl]tetracosanamide
• 化学式: C₄₈H₉₅NO₉
• 分子量: 830.3
• InChiKey: NJEKZVBGTWDZOP-WDNDPMGRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.4
• 重原子数：
  58
• 可旋转键数：
  42
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.98
• 拓扑面积：
  169
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE PROPHYLACTIC TREATMENT OF BACTERIAL SUPERINFECTIONS POST-INFLUENZA WITH INVARIANT NKT CELL AGONISTS
  申请人：INSERM - Institut National de la Santé et de la Recherche Médicale

  公开号：EP2903622A1

  公开（公告）日：2015-08-12
• METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
  申请人：INSERM (Institut National de la Santé et de la Recherche Médicale)

  公开号：EP3104864A1

  公开（公告）日：2016-12-21
• [EN] METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE PROPHYLACTIC TREATMENT OF BACTERIAL SUPERINFECTIONS POST-INFLUENZA WITH INVARIANT NKT CELL AGONISTS<br/>[FR] MÉTHODES ET COMPOSITIONS PHARMACEUTIQUES POUR LE TRAITEMENT PROPHYLACTIQUE DES SURINFECTIONS BACTÉRIENNES POST-GRIPPALES PAR DES AGONISTES DE CELLULES NKT INVARIANTS
  申请人：INSERM INST NAT DE LA SANTÉ ET DE LA RECH MÉDICALE

  公开号：WO2014053482A1

  公开（公告）日：2014-04-10

  The present invention relates to methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with iNKT cell agonists.
• [EN] METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE<br/>[FR] PROCÉDÉS ET COMPOSITIONS PHARMACEUTIQUES POUR LE TRAITEMENT D'EXACERBATIONS AIGUËS DE LA MALADIE PULMONAIRE OBSTRUCTIVE CHRONIQUE
  申请人：INSERM INST NAT DE LA SANTÉ ET DE LA RECH MÉDICALE

  公开号：WO2015121393A1

  公开（公告）日：2015-08-20

  The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease.In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of at least one NKT cell agonist.