4-(4-Aminophenyl)-6-(fluoromethyl)piperazin-2-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-Aminophenyl)-6-(fluoromethyl)piperazin-2-ol
• 英文别名: 4-(4-aminophenyl)-6-(fluoromethyl)piperazin-2-ol
• 化学式: C₁₁H₁₆FN₃O
• 分子量: 225.26
• InChiKey: YDPGTNODYCJWBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  61.5
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• SUBSTITUTED N-(3-(PYRIMIDIN-4-YL)PHENYL)ACRYLAMIDE ANALOGS AS TYROSINE RECEPTOR KINASE BTK INHIBITORS
  申请人：University Of Utah Research Foundation

  公开号：EP2903971A2

  公开（公告）日：2015-08-12
• [EN] SUBSTITUTED N-(3-(PYRIMIDIN-4-YL)PHENYL)ACRYLAMIDE ANALOGS AS TYROSINE RECEPTOR KINASE BTK INHIBITORS<br/>[FR] ANALOGUES DE N-(3-(PYRIMIDIN-4-YL)PHÉNYL) SUBSTITUÉ UTILISÉS EN TANT QU'INHIBITEURS DE RÉCEPTEUR TYROSINE KINASE BTK
  申请人：UNIV UTAH RES FOUND

  公开号：WO2014055934A2

  公开（公告）日：2014-04-10

  In one aspect, the invention relates to substituted N-(3-(pyrimidin-4- yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.