Hept-1-yn-3-amine;hydrochloride

• 分子结构分类: 有机化合物 - 乙炔化物 - 碳化物
• 英文名称: Hept-1-yn-3-amine;hydrochloride
• 英文别名: hept-1-yn-3-amine;hydrochloride
• 化学式: C7H14ClN
• 分子量: 147.64
• InChiKey: QZWUBKSCESOACF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.56
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• N-PROP-2-YNYL CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS
  申请人：Orion Corporation

  公开号：EP2903965A1

  公开（公告）日：2015-08-12
• METHODS OF REDUCTION OF INTERPATIENT VARIABILITY
  申请人：Gant Thomas G.

  公开号：US20100076087A1

  公开（公告）日：2010-03-25

  Disclosed herein are methods for the reduction of inter-patient variability of a drug, such as in one or more parameters including half-life (t 1/2 ), maximum plasma concentration (C max ), time at maximal plasma concentration (T max ), area under the time-versus-concentration curve (AUC). Also provided are methods of reducing side effects associated with drugs.
• [EN] N-PROP-2-YNYL CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS<br/>[FR] DÉRIVÉS DE N-PROP-2-YNYL-CARBOXAMIDE ET LEUR UTILISATION À TITRE D'ANTAGONISTES DE TRPA1
  申请人：ORION CORP

  公开号：WO2014053694A1

  公开（公告）日：2014-04-10

  Compounds of formula I, wherein A, B, X, Z and R1-R6, are as defined in the claims, exhibit TRPA 1 activity and are thus useful as TRPA1 modulators.