-diphenyl-<4-methyl-phenyl>-methan | 96871-77-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: -diphenyl-<4-methyl-phenyl>-methan
• 英文别名: bis-(4-methyl-trityl)-ether；Bis-(4-methyl-triphenylmethyl)-aether；Bis-(diphenyl-p-tolyl-methyl)-aether；Bis-(4-methyl-trityl)-aether；1-Methyl-4-[[(4-methylphenyl)-diphenylmethoxy]-diphenylmethyl]benzene
• CAS: 96871-77-1
• 化学式: C₄₀H₃₄O
• 分子量: 530.709
• InChiKey: SAJTWBNDOBECGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  盐酸 、 -diphenyl-<4-methyl-phenyl>-methan 生成 4-甲基三苯基甲醇
  参考文献：
  名称：

  Halford, Journal of the American Chemical Society, 1929, vol. 51, p. 2158

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 mercury(II) oxide 、 苯 作用下， 生成 -diphenyl-<4-methyl-phenyl>-methan
  参考文献：
  名称：

  Halford, Journal of the American Chemical Society, 1929, vol. 51, p. 2158

  摘要：

  DOI：

文献信息

• [EN] NUCLEOSIDE-LIPID COMPOUNDS WITH PH-SENSITIVE DIALKYLORTHOESTER CHAINS AND THEIR USE FOR TRANSPORTATION OR VECTORIZATION OF AT LEAST ONE THERAPEUTIC AGENT<br/>[FR] COMPOSÉS NUCLÉOSIDES-LIPIDES AVEC DES CHAÎNES DIALKYLORTHOESTER SENSIBLES AU PH ET LEUR UTILISATION POUR LE TRANSPORT OU LA VECTORISATION D'AU MOINS UN AGENT THÉRAPEUTIQUE
  申请人：UNIV BORDEAUX

  公开号：WO2016188868A1

  公开（公告）日：2016-12-01

  The invention relates to new nucleoside-lipid compounds with pH-sensitive dialkylorthoesterchains, to the process for their preparation and to their uses, in particular their use for transportation or vectorization of at least one therapeutic agent.

  这项发明涉及具有pH敏感二烷基正酯链的新核苷脂类化合物，涉及它们的制备过程以及它们的用途，特别是用于运输或载体化至少一种治疗剂的用途。
• Method of removing the triphenylmethane protecting group
  申请人：Radl Stanislav

  公开号：US20060287537A1

  公开（公告）日：2006-12-21

  A method of removing the triphenylmethane protecting group from 1-triphenylmethy1-5-(4′-subst. methyl-1,1′-biphenyl-2-yl)-1H-tetrazoles of general formula I wherein R represents the groups of formulae and where R 1 , R 2 and R 3 can be H, a halogen, an unbranched or branched C1-C5 alkyl, C1-C5 hydroxyalkyl, C1-C5 alkoxy, C1-C5 alkoxymethyl or benzyl, or wherein R 2 and R 3 can form together a saturated or unsaturated C5-C7 ring, optionally an unsubstituted or substituted aromatic ring, is carried out by solvolysis in a simple anhydrous C1 to C5 alcohol in a neutral or slightly basic medium. The method is suitable for the preparation of drugs, such as the potassium salts of losartan, irbesartan or valsartan or candesartan cilexetil.

  一种从一般式I的1-三苯甲基-5-(4'-取代甲基-1,1'-联苯基)-1H-四唑中去除三苯甲基保护基的方法，其中R代表式的基团，其中R1、R2和R3可以是H、卤素、直链或支链C1-C5烷基、C1-C5羟基烷基、C1-C5烷氧基、C1-C5烷氧甲基或苄基，或其中R2和R3可以共同形成饱和或不饱和的C5-C7环，可选地为未取代或取代的芳香环，通过在中性或稍微碱性介质中的简单无水C1到C5醇中进行溶剂解除。该方法适用于制备药物，例如洛卡新钾、厄贝沙坦钾、缬沙坦钾或坎地沙坦西酯盐。
• NUCLEOSIDE-LIPID COMPOUNDS WITH PH-SENSITIVE DIALKYLORTHOESTER CHAINS AND THEIR USE FOR TRANSPORTATION OR VECTORIZATION OF AT LEAST ONE THERAPEUTIC AGENT
  申请人：UNIVERSITE DE BORDEAUX

  公开号：EP3095790A1

  公开（公告）日：2016-11-23

  The invention relates to new nucleoside-lipid compounds with pH-sensitive dialkylorthoester chains, to the process for their preparation and to their uses, in particular their use for transportation or vectorization of at least one therapeutic agent.

  本发明涉及具有对 pH 值敏感的二烷基正酯链的新型核苷脂类化合物、其制备过程及其用途，特别是用于至少一种治疗剂的运输或载体化。
• Nucleoside-lipid compounds with pH-sensitive dialkylorthoester chains and their use for transportation or vectorization of at least one therapeutic agent
  申请人：UNIVERSITE DE BORDEAUX

  公开号：US10633408B2

  公开（公告）日：2020-04-28

  The invention relates to new nucleoside-lipid compounds with pH-sensitive dialkylorthoester chains, to the process for their preparation and to their uses, in particular their use for transportation or vectorization of at least one therapeutic agent.

  本发明涉及具有对 pH 值敏感的二烷基正酯链的新型核苷脂类化合物、其制备过程及其用途，特别是用于至少一种治疗剂的运输或载体化。
• 137. Tritylation and detritylation of active methylene compounds. Part I. Tritylation by various triarylmethanols
  作者：Saul Patai、Shlomo Dayagi

  DOI：10.1039/jr9620000716

  日期：——