P-P-P-rAdo.P-P-P-rGuo

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: P-P-P-rAdo.P-P-P-rGuo
• 英文别名: [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• 化学式: C20H32N10O27P6
• 分子量: 1030.4
• InChiKey: HBSCIOHSWWWKGH-YOCMHDSMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.96
• 重原子数：
  63
• 可旋转键数：
  16
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  574
• 氢给体数：
  15
• 氢受体数：
  32

文献信息

• Non-meiotic allele introgression
  申请人：Recombinetics, Inc.

  公开号：US10893667B2

  公开（公告）日：2021-01-19

  Methods, uses, and compositions for manipulating genomic DNA. Some of the embodiments of the invention provide for making a founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as TALENs or CRISPR with a preferred truncation. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell (optionally with a mismatch in the binding of the targeting endonuclease and the targeted site). Another embodiment includes processes of making a genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the animal from becoming sexually mature. One embodiment includes compositions and methods for making livestock with a polled allele, including migrating a polled allele into a bovine species without changing other genes or chromosomal portions.

  操纵基因组 DNA 的方法、用途和组合物。本发明的一些实施方案提供了一种完全不含所有计划外基因修饰的创始动物。本发明的一些实施方案是为了在不对基因组进行其他改变的情况下，消除已培育品种的基因缺陷。其他实施方案则针对特定的工具或过程，如 TALENs 或带有优选截断的 CRISPR。一个实施方案涉及将靶向内切酶系统和 HDR 模板引入细胞（可选择在靶向内切酶和靶向位点的结合中存在错配）。另一个实施方案包括制造转基因家畜的过程，该转基因家畜的基因组包括对性成熟有选择性的神经内分泌基因的失活，该基因的失活阻止了家畜的性成熟。一个实施方案包括制造具有花粉等位基因的家畜的组合物和方法，包括在不改变其他基因或染色体部分的情况下将花粉等位基因迁移到牛种中。
• Efficient non-meiotic allele introgression
  申请人：Recombinetics, Inc.

  公开号：US10959414B2

  公开（公告）日：2021-03-30

  Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site.

  动物间等位基因（包括SNPs）的导入方法、用途和动物。其中一个实施方案是将靶向内切酶系统和 HDR 模板导入细胞，靶向内切酶和靶位点的结合存在错配。
• CONTROL OF SEXUAL MATURATION IN ANIMALS
  申请人：Recombinetics, Inc.

  公开号：EP2914714A1

  公开（公告）日：2015-09-09
• HORNLESS LIVESTOCK
  申请人：Recombinetics, Inc.

  公开号：EP2943060A1

  公开（公告）日：2015-11-18
• EFFICIENT NON-MEIOTIC ALLELE INTROGRESSION
  申请人：Recombinetics, Inc.

  公开号：EP3039145A1

  公开（公告）日：2016-07-06