[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate;3-oxobutanoic acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate;3-oxobutanoic acid
• 化学式: C25H42N7O19P3S
• 分子量: 869.6
• InChiKey: MGFHAGGWEMOKAG-WCBKWELQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.62
• 重原子数：
  55
• 可旋转键数：
  20
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  402
• 氢给体数：
  11
• 氢受体数：
  24

文献信息

• [EN] MODIFIED MICROORGANISMS AND METHODS FOR PRODUCTION OF USEFUL PRODUCTS<br/>[FR] MICRO-ORGANISMES MODIFIÉS ET PROCÉDÉS POUR LA PRODUCTION DE PRODUITS UTILES
  申请人：ZUVASYNTHA LTD

  公开号：WO2016050842A1

  公开（公告）日：2016-04-07

  The invention provides non-naturally occurring microbial organisms and related methods, processes and materials wherein the microbial organisms includes a genetic modification which enhances production of 3-hydroxybutanal or a downstream product of 3- hydroxybutanal such as 1,3-butanediol from endogenous central metabolic intermediates such as acetyl CoA or pyruvate which are converted to acetaldehyde, whereby two molecules of acetaldehyde are condensed to form said 3-hydroxybutanal using an aldolase capable of accepting acetaldehyde as both the acceptor and donor in an aldol condensation. The aldolase may be a deoxyribose phosphate aldolase type enzyme, and is typically introduced into the organisms. The invention provides for energetically favorable pathways for production of 3-hydroxybutanal or downstream products thereof.

  该发明提供了非自然存在的微生物生物体及相关方法、过程和材料，其中微生物生物体包括一种基因修饰，增强了3-羟基丁醛或3-羟基丁醛的下游产物（如1,3-丁二醇）的产生，这些产物是从内源性中心代谢中间体（如乙酰辅酶A或丙酮酸）转化为乙醛，通过使用能够接受乙醛作为受体和给体进行醛缩反应的醛缩酶将两分子乙醛缩合形成所述的3-羟基丁醛。该醛缩酶可以是脱氧核糖磷酸醛缩酶类型的酶，并且通常被引入到生物体中。该发明提供了能量有利的途径，用于生产3-羟基丁醛或其下游产物。
• Terpene synthases for biofuel production and methods thereof
  申请人：National Technology & Engineering Solutions of Sandia, LLC

  公开号：US10400254B1

  公开（公告）日：2019-09-03

  The present invention relates to terpene synthases capable of degrading precursors into biofuel compounds, such as terpenoid compounds. In one instance, a transformed organism can include such terpene synthases, as well as vectors encoding such synthases. Methods of employing such synthases and organisms are also described herein.

  本发明涉及能够将前体降解为生物燃料化合物（如萜类化合物）的萜烯合成酶。在一种情况下，转化的生物体可以包括这种萜合成酶以及编码这种合成酶的载体。本文还描述了使用此类合成酶和生物体的方法。
• EP3201344A1
  申请人：——

  公开号：EP3201344A1

  公开（公告）日：2017-08-09
• MODIFIED MICROORGANISMS AND METHODS FOR PRODUCTION OF USEFUL PRODUCTS
  申请人：ZUVASYNTHA LIMITED

  公开号：US20170356016A1

  公开（公告）日：2017-12-14

  Non-naturally occurring microbial organisms and related methods, processes and materials are for microbial organisms that include a genetic modification which enhances production of 3-hydroxybutanal or a downstream product of 3-hydroxybutanal such as 1,3-butanediol from endogenous central metabolic intermediates such as acetyl CoA or pyruvate which are converted to acetaldehyde. Two molecules of acetaldehyde are condensed to form the 3-hydroxybutanal using an aldolase capable of accepting acetaldehyde as both the acceptor and donor in an aldol condensation. The aldolase may be a deoxyribose phosphate aldolase type enzyme, and is typically introduced into the organisms. Energetically favorable pathways produce 3-hydroxybutanal or downstream products thereof.
• [EN] ISOPROPANOL PRODUCTION BY BACTERIAL HOSTS<br/>[FR] PRODUCTION D'ISOPROPANOL PAR DES HÔTES BACTÉRIENS
  申请人：NOVOZYMES AS

  公开号：WO2014068010A1

  公开（公告）日：2014-05-08

  Provided herein are recombinant Lactobacillus host cells,comprising an active isopropanol pathway and a heterologous butyrate-acetoacetate CoA transferase gene. Also described are methods of using the recombinant Lactobacillus host cells to produce isopropanol and propylene.