5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid;(E,2S,3R)-2-aminooctadec-4-ene-1,3-diol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid;(E,2S,3R)-2-aminooctadec-4-ene-1,3-diol
• 化学式: C28H53N3O5S
• 分子量: 543.8
• InChiKey: JFVNVAWKCRFZNO-BYFYVAOPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.72
• 重原子数：
  37
• 可旋转键数：
  20
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  170
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• Aptamers and uses thereof
  申请人：Caris Science, Inc.

  公开号：US10942184B2

  公开（公告）日：2021-03-09

  Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.

  本发明提供了特异性适配体和适配体池的方法和组合物，它们能结合感兴趣的生物标记物，如微囊表面抗原或微囊表面抗原的功能片段。在各种实施方案中，本发明的适配体可用于诊断、预后或治疗过程，以筛选生物样本中生物标记物（如微囊）的存在或水平，确定这些标记物以提供诊断、预后或治疗读数。诊断、预后或治疗可能与癌症或其他疾病和失调有关。本发明还提供了促进适配体库筛选和适配体检测方法的方法和组合物。
• APTAMERS AND USES THEREOF
  申请人：Caris Science, Inc.

  公开号：EP2912182B1

  公开（公告）日：2021-12-08
• US9958448B2
  申请人：——

  公开号：US9958448B2

  公开（公告）日：2018-05-01
• [EN] APTAMERS AND USES THEREOF<br/>[FR] APTAMÈRES ET LEURS UTILISATIONS
  申请人：CARIS LIFE SCIENCES SWITZERLAND HOLDINGS S A R L

  公开号：WO2014068408A2

  公开（公告）日：2014-05-08

  Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as micro vesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.